You are here
Fetuin-A, type 2 diabetes, and risk of cardiovascular disease in older adults: the cardiovascular health study.
Monday,2013-01-14 16:59 America/Los_Angeles — poolea2
| Title | Fetuin-A, type 2 diabetes, and risk of cardiovascular disease in older adults: the cardiovascular health study. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Jensen, MK, Bartz, TM, Mukamal, KJ, Djoussé, L, Kizer, JR, Tracy, RP, Zieman, SJ, Rimm, EB, Siscovick, DS, Shlipak, M, Ix, JH |
| Journal | Diabetes Care |
| Volume | 36 |
| Issue | 5 |
| Pagination | 1222-8 |
| Date Published | 2013 May |
| ISSN | 1935-5548 |
| Keywords | Aged, Aged, 80 and over, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Female, Fetuins, Humans, Incidence, Longitudinal Studies, Male, Risk Factors |
| Abstract | <p><b>OBJECTIVE: </b>Fetuin-A, a hepatic secretory protein that simultaneously inhibits arterial calcification and insulin action, is associated with type 2 diabetes, but its association with cardiovascular disease (CVD) is uncertain. Preliminary studies suggest that the association of fetuin-A with CVD might differ among individuals with or without type 2 diabetes.</p><p><b>RESEARCH DESIGN AND METHODS: </b>This was a prospective study of 3,810 community-living individuals older than 65 years (511 with type 2 diabetes) and free of CVD in 1992 when fetuin-A levels were measured. Participants were followed-up for incident CVD through June 2008.</p><p><b>RESULTS: </b>Mean age was 75 years, and 61% were women; 1,456 participants had an incident CVD event (248 among individuals with type 2 diabetes). The association of fetuin-A with CVD was modified by type 2 diabetes (P interaction = 0.02). Higher fetuin-A was associated with lower CVD risk among persons without type 2 diabetes [hazard ratio per SD 0.1 g/L higher fetuin-A, 0.93 (95% CI, 0.88-0.99)], whereas a trend in the opposite direction was observed among individuals with type 2 diabetes, although it was not statistically significant [1.07 (0.93-1.22)]. Among individuals without type 2 diabetes, similar effect modification was observed by obesity and insulin resistance. Consistently, higher fetuin-A was associated with lower CVD risk only in the subgroups without obesity or with HOMA-IR below the median [0.91 (0.85-0.97) and 0.87 (0.79-0.95), respectively].</p><p><b>CONCLUSIONS: </b>The association of fetuin-A with risk of CVD differs among elderly individuals with and without insulin resistance or type 2 diabetes.</p> |
| DOI | 10.2337/dc12-1591 |
| Alternate Journal | Diabetes Care |
| PubMed ID | 23250801 |
| PubMed Central ID | PMC3631840 |
| Grant List | U01 HL080295 / HL / NHLBI NIH HHS / United States N01 HC075150 / HC / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States N01 HC-85079 / HC / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States R01 HL094555 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States N01-HC85239 / HC / NHLBI NIH HHS / United States N01HC-85086 / HC / NHLBI NIH HHS / United States N01 HC085079 / HC / NHLBI NIH HHS / United States N01 HC-54133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States |