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A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
Tuesday,2013-10-01 09:04 America/Los_Angeles — poolea2
| Title | A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Monda, KL, Chen, GK, Taylor, KC, Palmer, C, Edwards, TL, Lange, LA, C Y Ng, M, Adeyemo, AA, Allison, MA, Bielak, LF, Chen, G, Graff, M, Irvin, MR, Rhie, SK, Li, G, Liu, Y, Liu, Y, Lu, Y, Nalls, MA, Sun, YV, Wojczynski, MK, Yanek, LR, Aldrich, MC, Ademola, A, Amos, CI, Bandera, EV, Bock, CH, Britton, A, Broeckel, U, Cai, Q, Caporaso, NE, Carlson, CS, Carpten, J, Casey, G, Chen, W-M, Chen, F, Chen, Y-derI, Chiang, CWK, Coetzee, GA, Demerath, E, Deming-Halverson, SL, Driver, RW, Dubbert, P, Feitosa, MF, Feng, Y, Freedman, BI, Gillanders, EM, Gottesman, O, Guo, X, Haritunians, T, Harris, T, Harris, CC, Hennis, AJM, Hernandez, DG, McNeill, LH, Howard, TD, Howard, BV, Howard, VJ, Johnson, KC, Kang, SJ, Keating, BJ, Kolb, S, Kuller, LH, Kutlar, A, Langefeld, CD, Lettre, G, Lohman, K, Lotay, V, Lyon, H, Manson, JAE, Maixner, W, Meng, YA, Monroe, KR, Morhason-Bello, I, Murphy, AB, Mychaleckyj, JC, Nadukuru, iv, R, Nathanson, KL, Nayak, U, N'diaye, A, Nemesure, B, Wu, S-Y, M Leske, C, Neslund-Dudas, C, Neuhouser, M, Nyante, S, Ochs-Balcom, H, Ogunniyi, A, Ogundiran, TO, Ojengbede, O, Olopade, OI, Palmer, JR, Ruiz-Narvaez, EA, Palmer, ND, Press, MF, Rampersaud, E, Rasmussen-Torvik, LJ, Rodriguez-Gil, JL, Salako, B, Schadt, EE, Schwartz, AG, Shriner, DA, Siscovick, D, Smith, SB, Wassertheil-Smoller, S, Speliotes, EK, Spitz, MR, Sucheston, L, Taylor, H, Tayo, BO, Tucker, MA, Van Den Berg, DJ, Edwards, DRVelez, Wang, Z, Wiencke, JK, Winkler, TW, Witte, JS, Wrensch, M, Wu, X, Yang, JJ, Levin, AM, Young, TR, Zakai, NA, Cushman, M, Zanetti, KA, Zhao, JH, Zhao, W, Zheng, Y, Zhou, J, Ziegler, RG, Zmuda, JM, Fernandes, JK, Gilkeson, GS, Kamen, DL, Hunt, KJ, Spruill, IJ, Ambrosone, CB, Ambs, S, Arnett, DK, Atwood, L, Becker, DM, Berndt, SI, Bernstein, L, Blot, WJ, Borecki, IB, Bottinger, EP, Bowden, DW, Burke, G, Chanock, SJ, Cooper, RS, Ding, J, Duggan, D, Evans, MK, Fox, C, W Garvey, T, Bradfield, JP, Hakonarson, H, Grant, SFA, Hsing, A, Chu, L, Hu, JJ, Huo, D, Ingles, SA, John, EM, Jordan, JM, Kabagambe, EK, Kardia, SLR, Kittles, RA, Goodman, PJ, Klein, EA, Kolonel, LN, Le Marchand, L, Liu, S, McKnight, B, Millikan, RC, Mosley, TH, Padhukasahasram, B, L Williams, K, Patel, SR, Peters, U, Pettaway, CA, Peyser, PA, Psaty, BM, Redline, S, Rotimi, CN, Rybicki, BA, Sale, MM, Schreiner, PJ, Signorello, LB, Singleton, AB, Stanford, JL, Strom, SS, Thun, MJ, Vitolins, M, Zheng, W, Moore, JH, Williams, SM, Ketkar, S, Zhu, X, Zonderman, AB, Kooperberg, C, Papanicolaou, GJ, Henderson, BE, Reiner, AP, Hirschhorn, JN, Loos, RJF, North, KE, Haiman, CA |
| Corporate/Institutional Authors | NABEC Consortium, UKBEC Consortium, BioBank Japan Project, AGEN Consortium |
| Journal | Nat Genet |
| Volume | 45 |
| Issue | 6 |
| Pagination | 690-6 |
| Date Published | 2013 Jun |
| ISSN | 1546-1718 |
| Keywords | African Americans, Body Mass Index, Case-Control Studies, Gene Frequency, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Obesity, Polymorphism, Single Nucleotide |
| Abstract | <p>Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10(-11)) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10(-10)). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 × 10(-8)). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 × 10(-7)), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations.</p> |
| DOI | 10.1038/ng.2608 |
| Alternate Journal | Nat. Genet. |
| PubMed ID | 23583978 |
| PubMed Central ID | PMC3694490 |
| Grant List | U01-HL054512 / HL / NHLBI NIH HHS / United States ES011126 / ES / NIEHS NIH HHS / United States U01 HL054472 / HL / NHLBI NIH HHS / United States UL1RR025005 / RR / NCRR NIH HHS / United States CA54281 / CA / NCI NIH HHS / United States N02-HL-6-4278 / HL / NHLBI NIH HHS / United States R01 HL071025 / HL / NHLBI NIH HHS / United States R01-HL-088215 / HL / NHLBI NIH HHS / United States UL1 RR033176 / RR / NCRR NIH HHS / United States R01 AI061774 / AI / NIAID NIH HHS / United States R01 HL053353 / HL / NHLBI NIH HHS / United States U01 HL054471 / HL / NHLBI NIH HHS / United States U19 CA148127 / CA / NCI NIH HHS / United States CA73629 / CA / NCI NIH HHS / United States N01-HC-45205 / HC / NHLBI NIH HHS / United States K23 DK080145 / DK / NIDDK NIH HHS / United States P20 GM103534 / GM / NIGMS NIH HHS / United States N01-HC-95162 / HC / NHLBI NIH HHS / United States UL1RR033176 / RR / NCRR NIH HHS / United States CA77305 / CA / NCI NIH HHS / United States UL1TR000124 / TR / NCATS NIH HHS / United States RC2 CA148085 / CA / NCI NIH HHS / United States Z01-AG000513 / AG / NIA NIH HHS / United States P30 CA016672 / CA / NCI NIH HHS / United States ES007784 / ES / NIEHS NIH HHS / United States R01 HG003054 / HG / NHGRI NIH HHS / United States N01-HC-05187 / HC / NHLBI NIH HHS / United States N01 HC048050 / HC / NHLBI NIH HHS / United States N01 HC095170 / HC / NHLBI NIH HHS / United States CA88164 / CA / NCI NIH HHS / United States R01-HL-071252 / HL / NHLBI NIH HHS / United States R01 ES006717 / ES / NIEHS NIH HHS / United States S06GM008016-380111 / GM / NIGMS NIH HHS / United States R01 HL071251 / HL / NHLBI NIH HHS / United States R01 HL087698 / HL / NHLBI NIH HHS / United States R01 HL101161 / HL / NHLBI NIH HHS / United States N01 HC048047 / HC / NHLBI NIH HHS / United States R01 CA089085 / CA / NCI NIH HHS / United States R01 HL046380 / HL / NHLBI NIH HHS / United States CA127298 / CA / NCI NIH HHS / United States R01-HL086718 / HL / NHLBI NIH HHS 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