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Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts.

Tuesday,2013-10-01 09:13 America/Los_Angeles — poolea2
TitleAdhesion molecules, endothelin-1 and lung function in seven population-based cohorts.
Publication TypeJournal Article
Year of Publication2013
AuthorsOelsner, EC, Pottinger, TD, Burkart, KM, Allison, M, Buxbaum, SG, Hansel, NN, Kumar, R, Larkin, EK, Lange, LA, Loehr, LR, London, SJ, O'Connor, GT, Papanicolaou, G, Petrini, MF, Rabinowitz, D, Raghavan, S, Redline, S, Thyagarajan, B, Tracy, RP, Wilk, JB, White, WB, Rich, SS, Barr, RG
JournalBiomarkers
Volume18
Issue3
Pagination196-203
Date Published2013 May
ISSN1366-5804
Other NumbersCollaborator
KeywordsAfrican Continental Ancestry Group, Biomarkers, Cohort Studies, E-Selectin, Endothelin-1, Endothelium, Vascular, European Continental Ancestry Group, Female, Gene Expression, Humans, Intercellular Adhesion Molecule-1, Lung, Male, Middle Aged, P-Selectin, Pulmonary Disease, Chronic Obstructive, Respiratory Function Tests, Spirometry
Abstract<p><b>CONTEXT: </b>Endothelial function is abnormal in chronic obstructive pulmonary disease (COPD); whether endothelial dysfunction causes COPD is unknown.</p><p><b>OBJECTIVE: </b>Test associations of endothelial biomarkers with FEV1 using instrumental variables.</p><p><b>METHODS: </b>Among 26 907 participants with spirometry, ICAM-1, P-selectin, E-selectin and endothelin-1 were measured in subsets.</p><p><b>RESULTS: </b>ICAM-1 and P-selectin were inversely associated with FEV1 among European-Americans (-29 mL and -34 mL per standard deviation of log-transformed biomarker, p < 0.001), as was endothelin-1 among African-Americans (-22 mL, p = 0.008). Genetically-estimated ICAM-1 and P-selectin were not significantly associated with FEV1. The instrumental variable for endothelin-1 was non-informative.</p><p><b>CONCLUSION: </b>Although ICAM-1, P-selectin and endothelin-1 were inversely associated with FEV1, associations for ICAM-1 and P-selectin do not appear causal.</p>
DOI10.3109/1354750X.2012.762805
Alternate JournalBiomarkers
PubMed ID23557128
PubMed Central IDPMC3890095
Grant ListUL1RR025005 / RR / NCRR NIH HHS / United States
N01-HC-25195 / HC / NHLBI NIH HHS / United States
R01-HL-077612 / HL / NHLBI NIH HHS / United States
HL-096917 / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
N01-HC-45205 / HC / NHLBI NIH HHS / United States
N01-HC-95162 / HC / NHLBI NIH HHS / United States
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U01 HL096812 / HL / NHLBI NIH HHS / United States
N01-HC-05187 / HC / NHLBI NIH HHS / United States
N01HC95160 / HL / NHLBI NIH HHS / United States
R01 HL071251 / HL / NHLBI NIH HHS / United States
R01 HL046380 / HL / NHLBI NIH HHS / United States
R01 HL053560 / HL / NHLBI NIH HHS / United States
R01-HL-071258 / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
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R56 AG020098 / AG / NIA NIH HHS / United States
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RC1 HL100543 / HL / NHLBI NIH HHS / United States
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