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Evaluating subject-level incremental values of new markers for risk classification rule.
Tuesday,2013-10-01 11:44 America/Los_Angeles — poolea2
| Title | Evaluating subject-level incremental values of new markers for risk classification rule. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Cai, T, Tian, L, Lloyd-Jones, D, Wei, LJ |
| Journal | Lifetime Data Anal |
| Volume | 19 |
| Issue | 4 |
| Pagination | 547-67 |
| Date Published | 2013 Oct |
| ISSN | 1572-9249 |
| Keywords | Aged, Antihypertensive Agents, Biomarkers, Biostatistics, C-Reactive Protein, Confidence Intervals, Coronary Disease, Female, Humans, Risk, Risk Factors, Statistics, Nonparametric, United States |
| Abstract | <p>Suppose that we need to classify a population of subjects into several well-defined ordered risk categories for disease prevention or management with their "baseline" risk factors/markers. In this article, we present a systematic approach to identify subjects using their conventional risk factors/markers who would benefit from a new set of risk markers for more accurate classification. Specifically for each subgroup of individuals with the same conventional risk estimate, we present inference procedures for the reclassification and the corresponding correct re-categorization rates with the new markers. We then apply these new tools to analyze the data from the Cardiovascular Health Study sponsored by the US National Heart, Lung, and Blood Institute. We used Framingham risk factors plus the information of baseline anti-hypertensive drug usage to identify adult American women who may benefit from the measurement of a new blood biomarker, CRP, for better risk classification in order to intensify prevention of coronary heart disease for the subsequent 10 years.</p> |
| DOI | 10.1007/s10985-013-9272-6 |
| Alternate Journal | Lifetime Data Anal |
| PubMed ID | 23807696 |
| PubMed Central ID | PMC4527584 |
| Grant List | N01HC55222 / HC / NHLBI NIH HHS / United States N01HC85080 / HC / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01HC85081 / HC / NHLBI NIH HHS / United States N01HC85079 / HC / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States N01HC85086 / HC / NHLBI NIH HHS / United States N01HC85082 / HC / NHLBI NIH HHS / United States HHSN268200800007C / / PHS HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States HHSN268201200036C / / PHS HHS / United States N01HC85083 / HC / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States |