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Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
Wednesday,2013-10-02 12:24 America/Los_Angeles — poolea2
| Title | Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Artigas, MSoler, Loth, DW, Wain, LV, Gharib, SA, Obeidat, M'en, Tang, W, Zhai, G, Zhao, JH, Smith, AVernon, Huffman, JE, Albrecht, E, Jackson, CM, Evans, DM, Cadby, G, Fornage, M, Manichaikul, A, Lopez, LM, Johnson, T, Aldrich, MC, Aspelund, T, Barroso, I, Campbell, H, Cassano, PA, Couper, DJ, Eiriksdottir, G, Franceschini, N, Garcia, M, Gieger, C, Gislason, GKjartan, Grkovic, I, Hammond, CJ, Hancock, DB, Harris, TB, Ramasamy, A, Heckbert, SR, Heliövaara, M, Homuth, G, Hysi, PG, James, AL, Jankovic, S, Joubert, BR, Karrasch, S, Klopp, N, Koch, B, Kritchevsky, SB, Launer, LJ, Liu, Y, Loehr, LR, Lohman, K, Loos, RJF, Lumley, T, Balushi, KAAl, Ang, WQ, R Barr, G, Beilby, J, Blakey, JD, Boban, M, Boraska, V, Brisman, J, Britton, JR, Brusselle, GG, Cooper, C, Curjuric, I, Dahgam, S, Deary, IJ, Ebrahim, S, Eijgelsheim, M, Francks, C, Gaysina, D, Granell, R, Gu, X, Hankinson, JL, Hardy, R, Harris, SE, Henderson, J, Henry, A, Hingorani, AD, Hofman, A, Holt, PG, Hui, J, Hunter, ML, Imboden, M, Jameson, KA, Kerr, SM, Kolcic, I, Kronenberg, F, Liu, JZ, Marchini, J, McKeever, T, Morris, AD, Olin, A-C, Porteous, DJ, Postma, DS, Rich, SS, Ring, SM, Rivadeneira, F, Rochat, T, Sayer, AA, Sayers, I, Sly, PD, Smith, GD, Sood, A, Starr, JM, Uitterlinden, AG, Vonk, JM, S Wannamethee, G, Whincup, PH, Wijmenga, C, O Williams, D, Wong, A, Mangino, M, Marciante, KD, McArdle, WL, Meibohm, B, Morrison, AC, North, KE, Omenaas, E, Palmer, LJ, Pietiläinen, KH, Pin, I, Ek, OPola Sbrev, Pouta, A, Psaty, BM, Hartikainen, A-L, Rantanen, T, Ripatti, S, Rotter, JI, Rudan, I, Rudnicka, AR, Schulz, H, Shin, S-Y, Spector, TD, Surakka, I, Vitart, V, Völzke, H, Wareham, NJ, Warrington, NM, Wichmann, H-E, Wild, SH, Wilk, JB, Wjst, M, Wright, AF, Zgaga, L, Zemunik, T, Pennell, CE, Nyberg, F, Kuh, D, Holloway, JW, H Boezen, M, Lawlor, DA, Morris, RW, Probst-Hensch, N, Kaprio, J, Wilson, JF, Hayward, C, Kähönen, M, Heinrich, J, Musk, AW, Jarvis, DL, Gläser, S, Jarvelin, M-R, Stricker, BHCh, Elliott, P, O'Connor, GT, Strachan, DP, London, SJ, Hall, IP, Gudnason, V, Tobin, MD |
| Corporate/Institutional Authors | International Lung Cancer Consortium, GIANT Consortium |
| Journal | Nat Genet |
| Volume | 43 |
| Issue | 11 |
| Pagination | 1082-90 |
| Date Published | 2011 Sep 25 |
| ISSN | 1546-1718 |
| Keywords | Child, European Continental Ancestry Group, Genome-Wide Association Study, Humans, Pulmonary Disease, Chronic Obstructive, Respiratory Function Tests |
| Abstract | <p>Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.</p> |
| DOI | 10.1038/ng.941 |
| Alternate Journal | Nat. Genet. |
| PubMed ID | 21946350 |
| PubMed Central ID | PMC3267376 |
| Grant List | M01-RR00425 / RR / NCRR NIH HHS / United States HHSN268201100012C / HL / NHLBI NIH HHS / United States UL1RR025005 / RR / NCRR NIH HHS / United States R01 ES015794 / ES / NIEHS NIH HHS / United States N02-HL-6-4278 / HL / NHLBI NIH HHS / United States CZB/4/710 / / Chief Scientist Office / United Kingdom CA55769 / CA / NCI NIH HHS / United States HHSN268201100009I / HL / NHLBI NIH HHS / United States G0401540 / / Medical Research Council / United Kingdom U19 CA148127 / CA / NCI NIH HHS / United States N01-HC-45205 / HC / NHLBI NIH HHS / United States R01 MH063706 / MH / NIMH NIH HHS / United States CZD/16/6/2 / / Chief Scientist Office / United Kingdom N01-HC-95162 / HC / NHLBI NIH HHS / United States G0801056 / / Medical Research Council / United Kingdom MOP-82893 / / Canadian Institutes of Health Research / Canada G9901462 / / Medical Research Council / United Kingdom R01 HL-071022 / HL / NHLBI NIH HHS / United States MC_UP_A620_1015 / / Medical Research Council / United Kingdom N01AG12100 / AG / NIA NIH HHS / United States N01-HC-05187 / HC / NHLBI NIH HHS / United States 268201100011C / / PHS HHS / United States R01 HL071251 / HL / NHLBI NIH HHS / United States N01 HC-25195 / HC / NHLBI NIH HHS / United States 268201100005C / / PHS HHS / United States PG/97012 / / British Heart Foundation / United Kingdom N01-HC-85085 / HC / NHLBI NIH HHS / United States R01HL59367 / HL / NHLBI NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States R01 HL-074104 / HL / NHLBI NIH HHS / United States R01 HL071259 / HL / NHLBI NIH HHS / United States UL1 RR025005 / RR / NCRR NIH HHS / United States 268201100007C / / PHS HHS / United States R01 AG015928 / AG / NIA NIH HHS / United States ES015794 / ES / NIEHS NIH HHS / United States N01 AG062101 / AG / NIA NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States R01 HL087679 / HL / NHLBI NIH HHS / United States G20234 / 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