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Impact of inflammatory biomarkers on relation of high density lipoprotein-cholesterol with incident coronary heart disease: cardiovascular Health Study.
Tuesday,2013-12-10 10:48 America/Los_Angeles — poolea2
| Title | Impact of inflammatory biomarkers on relation of high density lipoprotein-cholesterol with incident coronary heart disease: cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Tehrani, DM, Gardin, JM, Yanez, D, Hirsch, CH, Lloyd-Jones, DM, Stein, PK, Wong, ND |
| Journal | Atherosclerosis |
| Volume | 231 |
| Issue | 2 |
| Pagination | 246-51 |
| Date Published | 2013 Dec |
| ISSN | 1879-1484 |
| Keywords | 1-Alkyl-2-acetylglycerophosphocholine Esterase, African Americans, Aged, Biomarkers, C-Reactive Protein, Cardiovascular Diseases, Cholesterol, HDL, Coronary Disease, European Continental Ancestry Group, Female, Humans, Incidence, Inflammation, Interleukin-6, Male, Middle Aged, Proportional Hazards Models, Prospective Studies, Risk Factors |
| Abstract | <p><b>BACKGROUND: </b>Inflammatory factors and low HDL-C relate to CHD risk, but whether inflammation attenuates any protective association of high HDL-C is unknown.</p><p><b>OBJECTIVE: </b>Investigate inflammatory markers' individual and collective impact on the association of HDL-C with incident coronary heart disease (CHD).</p><p><b>METHODS: </b>In 3888 older adults without known cardiovascular disease (CVD), we examined if the inflammatory markers C-reactive protein (CRP), interleukin-6 (IL-6), and lipoprotein-associated phospholipase A2 (Lp-PLA₂) modify the relation of HDL-C with CHD. HDL-C, CRP, IL-6, and Lp-PLA₂ values were grouped as using gender-specific tertiles. Also, an inflammation index of z-score sums for CRP, IL-6, and Lp-PLA₂ was categorized into tertiles. We calculated CHD incidence for each HDL-C/inflammation group and performed Cox regression, adjusted for standard CVD risk factors and triglycerides to examine the relationship of combined HDL-C-inflammation groups with incident events.</p><p><b>RESULTS: </b>CHD incidence (per 1000 person years) was higher for higher levels of CRP, IL-6, and the index, and lower for higher levels of HDL-C. Compared to high HDL-C/low-inflammation categories (referent), adjusted HRs for incident CHD were increased for those with high HDL-C and high CRP (HR = 1.50, p < 0.01) or highest IL-6 tertile (HR = 1.40, p < 0.05), but not with highest Lp-PLA₂ tertile. Higher CHD incidence was similarly seen for those with intermediate or low HDL-C accompanied by high CRP, high IL-6, or a high inflammatory index.</p><p><b>CONCLUSION: </b>The protective relation of high HDL-C for incident CHD appears to be attenuated by greater inflammation.</p> |
| DOI | 10.1016/j.atherosclerosis.2013.08.036 |
| Alternate Journal | Atherosclerosis |
| PubMed ID | 24267235 |
| PubMed Central ID | PMC3858257 |
| Grant List | AG-20098 / AG / NIA NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States AG-027058 / AG / NIA NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States HHSN268201200036C / / PHS HHS / United States HL080295 / HL / NHLBI NIH HHS / United States N01-HC-85239 / HC / NHLBI NIH HHS / United States AG-023629 / AG / NIA NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States |
ePub date:
2013-09-05