You are here
Height and risk of sudden cardiac death: the Atherosclerosis Risk in Communities and Cardiovascular Health studies.
Thursday,2013-12-26 13:18 America/Los_Angeles — poolea2
| Title | Height and risk of sudden cardiac death: the Atherosclerosis Risk in Communities and Cardiovascular Health studies. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Rosenberg, MA, Lopez, FL, Bůzková, P, Adabag, S, Chen, LY, Sotoodehnia, N, Kronmal, RA, Siscovick, DS, Alonso, A, Buxton, A, Folsom, AR, Mukamal, KJ |
| Journal | Ann Epidemiol |
| Volume | 24 |
| Issue | 3 |
| Pagination | 174-179.e2 |
| Date Published | 2014 Mar |
| ISSN | 1873-2585 |
| Keywords | Adult, Aged, Atherosclerosis, Body Height, Coronary Disease, Death, Sudden, Cardiac, Female, Humans, Hypertension, Incidence, Male, Middle Aged, Population Surveillance, Prospective Studies, Risk Factors |
| Abstract | <p><b>PURPOSE: </b>Sudden cardiac death (SCD) is an important cause of mortality in the adult population. Height has been associated with cardiac hypertrophy and an increased risk of arrhythmias but also with decreased risk of coronary heart disease, suggesting a complex association with SCD.</p><p><b>METHODS: </b>We examined the association of adult height with the risk of physician-adjudicated SCD in two large population-based cohorts: the Cardiovascular Health Study and the Atherosclerosis Risk in Communities study.</p><p><b>RESULTS: </b>Over an average follow-up time of 11.7 years in Cardiovascular Health Study, there were 199 (3.6%) cases of SCD among 5556 participants. In Atherosclerosis Risk in Communities study, over 12.6 years, there were 227 (1.5%) cases of SCD among 15,633 participants. In both cohorts, there was a trend toward decreased SCD with taller height. In fixed effects meta-analysis, the pooled hazard ratio per 10 cm of height was 0.84; 95% confidence interval, 0.73-0.98; P = .03. The association of increased height with lower risk of SCD was slightly attenuated after inclusion of risk factors associated with height, such as hypertension and left ventricular hypertrophy. The association appeared stronger among men than women in both cohorts.</p><p><b>CONCLUSIONS: </b>In two population-based prospective cohorts of different ages, greater height was associated with lower risk of SCD.</p> |
| DOI | 10.1016/j.annepidem.2013.11.008 |
| Alternate Journal | Ann Epidemiol |
| PubMed ID | 24360853 |
| PubMed Central ID | PMC3945001 |
| Grant List | N01HC85080 / HC / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01HC85081 / HC / NHLBI NIH HHS / United States N01HC85079 / HC / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States N01HC85086 / HC / NHLBI NIH HHS / United States N01HC85082 / HC / NHLBI NIH HHS / United States HHSN268200800007C / / PHS HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States HHSN268201200036C / / PHS HHS / United States HL080295 / HL / NHLBI NIH HHS / United States N01HC85083 / HC / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States AG023629 / AG / NIA NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States N01 HC55222 / HC / NHLBI NIH HHS / United States |