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Sleep and insulin-like growth factors in the Cardiovascular Health Study.
Thursday,2013-12-26 13:32 America/Los_Angeles — poolea2
| Title | Sleep and insulin-like growth factors in the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Shah, N, Rice, T, Tracy, D, Rohan, T, Bůzková, P, Newman, A, Kaplan, RC |
| Journal | J Clin Sleep Med |
| Volume | 9 |
| Issue | 12 |
| Pagination | 1245-51 |
| Date Published | 2013 Dec 15 |
| ISSN | 1550-9397 |
| Keywords | Aged, Cardiovascular Diseases, Cohort Studies, Cross-Sectional Studies, Female, Geriatric Assessment, Health Surveys, Humans, Insulin-Like Growth Factor Binding Protein 1, Insulin-Like Growth Factor Binding Protein 3, Insulin-Like Growth Factor I, Male, Sex Distribution, Sleep, Sleep Apnea, Obstructive, Somatomedins, United States |
| Abstract | <p><b>STUDY OBJECTIVES: </b>Sleep and sleep disordered breathing (obstructive sleep apnea [OSA]) are known to affect the growth hormone/insulin-like growth factor (GH/IGF) axis. There are few relevant population studies in this area, particularly in the elderly. We conducted this study to investigate the relationship between sleep (architecture and OSA) and circulating IGF-I (insulin-like growth factor-1), IGFBP-1 (insulin-like growth factor binding protein-1), and IGFBP-3 (insulin-like growth factor binding protein-3) levels in an elderly population.</p><p><b>DESIGN SETTING: </b>Cross-sectional analysis of participants from the year 9 visit of the Cardiovascular Health Study (CHS) who were enrolled in the Sleep Heart Health Study (SHHS).</p><p><b>PATIENTS OR PARTICIPANTS: </b>1,233 elderly participants from the CHS and SHHS.</p><p><b>MEASUREMENTS AND RESULTS: </b>The mean age of males (n = 526) and females (n = 697) was 77 years. The mean value of IGF-I (ng/mL) in males was 112.4 vs. 97.1 in females (p < 0.01). Mean IGFBP-1 and IGFBP-3 levels were higher in females than males (p < 0.01). As expected, slow wave sleep was better preserved in females compared to males (22% total sleep time vs. 9% total sleep time, p < 0.01). Furthermore, as expected, OSA (apneahypopnea index [AHI] ≥ 5/h) was more prevalent in males compared to females (60% vs. 46%, p < 0.01). Multivariable linear regression was used to determine the relationship between objective sleep parameters and circulating IGF-I, IGFBP-1, and IGFBP-3 levels, with adjustment for age, sex, race, BMI, diabetes, estrogen use, progestin use, and physical activity. We did not detect a significant association between slow wave sleep (SWS) (per 5 min) and IGF-I, IGFBP-1, and IGFBP-3 levels (ng/mL). We found no significant linear association between OSA (AHI ≥ 5/h) and IGF-I, IGFBP-1, and IGFBP-3 levels. Gender-stratification of the entire cohort did not alter these findings. Sensitivity analyses excluding diabetics revealed that moderate OSA (AHI ≥ 5 and < 15) is inversely associated with IGFBP-3 levels in women. Conclusions The relationship between SWS and GH/IGF system is not significant in the elderly. Furthermore, OSA does not appear to adversely influence the GH/IGF axis, as reported in younger individuals. Whether our study findings are due to diminished GH/IGF-I axis activity in elderly needs further investigation by replication in other large population based elderly cohorts.</p> |
| DOI | 10.5664/jcsm.3260 |
| Alternate Journal | J Clin Sleep Med |
| PubMed ID | 24340285 |
| PubMed Central ID | PMC3836334 |
| Grant List | N01HC55222 / HC / NHLBI NIH HHS / United States P30 AG024827 / AG / NIA NIH HHS / United States N01HC85080 / HC / NHLBI NIH HHS / United States HL53934 / HL / NHLBI NIH HHS / United States N01HC85081 / HC / NHLBI NIH HHS / United States N01HC85079 / HC / NHLBI NIH HHS / United States 01HC85086 / HC / NHLBI NIH HHS / United States T32 AG000181 / AG / NIA NIH HHS / United States N01HC85082 / HC / NHLBI NIH HHS / United States HL080295 / HL / NHLBI NIH HHS / United States N01HC85083 / HC / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States |