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No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population.
Tuesday,2014-04-01 11:56 America/Los_Angeles — poolea2
| Title | No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Dumitrescu, L, Carty, CL, Franceschini, N, Hindorff, LA, Cole, SA, Bůzková, P, Schumacher, FR, Eaton, CB, Goodloe, RJ, Duggan, DJ, Haessler, J, Cochran, B, Henderson, BE, Cheng, I, Johnson, KC, Carlson, CS, Love, S-A, Brown-Gentry, K, Nato, AQ, Quibrera, M, Shohet, RV, Ambite, JLuis, Wilkens, LR, Le Marchand, L, Haiman, CA, Buyske, S, Kooperberg, C, North, KE, Fornage, M, Crawford, DC |
| Journal | Hum Genet |
| Volume | 132 |
| Issue | 12 |
| Pagination | 1427-31 |
| Date Published | 2013 Dec |
| ISSN | 1432-1203 |
| Keywords | Cholesterol, HDL, Cholesterol, LDL, Cohort Studies, Ethnic Groups, Female, Gene Frequency, Gene-Environment Interaction, Genetics, Population, Genome-Wide Association Study, Humans, Lipid Metabolism, Male, Polymorphism, Single Nucleotide, Prevalence, Smoking, Triglycerides, Young Adult |
| Abstract | <p>Genome-wide association studies (GWAS) have identified many variants that influence high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and/or triglycerides. However, environmental modifiers, such as smoking, of these known genotype-phenotype associations are just recently emerging in the literature. We have tested for interactions between smoking and 49 GWAS-identified variants in over 41,000 racially/ethnically diverse samples with lipid levels from the Population Architecture Using Genomics and Epidemiology (PAGE) study. Despite their biological plausibility, we were unable to detect significant SNP × smoking interactions.</p> |
| DOI | 10.1007/s00439-013-1375-3 |
| Alternate Journal | Hum. Genet. |
| PubMed ID | 24100633 |
| PubMed Central ID | PMC3895337 |
| Grant List | N0144221 / / PHS HHS / United States N01-HC-05187 / HC / NHLBI NIH HHS / United States U01CA98758 / CA / NCI NIH HHS / United States U01 HL65520 / HL / NHLBI NIH HHS / United States T32 GM080178 / GM / NIGMS NIH HHS / United States U01 HG004790 / HG / NHGRI NIH HHS / United States N01-HC-48047 / HC / NHLBI NIH HHS / United States U01 HL65521 / HL / NHLBI NIH HHS / United States U01 HG004802 / HG / NHGRI NIH HHS / United States U01 HL41642 / HL / NHLBI NIH HHS / United States N01WH32100-2 / WH / WHI NIH HHS / United States U01CA136792 / CA / NCI NIH HHS / United States N01WH32108-9 / WH / WHI NIH HHS / United States U01HG004803 / HG / NHGRI NIH HHS / United States AG-20098 / AG / NIA NIH HHS / United States N01-HC-95095 / HC / NHLBI NIH HHS / United States U01HG004802 / HG / NHGRI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01WH42107-26 / WH / WHI NIH HHS / United States N01-HC-48050 / HC / NHLBI NIH HHS / United States U01 HL41654 / HL / NHLBI NIH HHS / United States AG-027058 / AG / NIA NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States U01 HL41652 / HL / NHLBI NIH HHS / United States N01WH32122 / WH / WHI NIH HHS / United States U01 HG004803 / HG / NHGRI NIH HHS / United States N01-HC-48049 / HC / NHLBI NIH HHS / United States U01HG004798 / HG / NHGRI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States N01WH32105-6 / WH / WHI NIH HHS / United States N01HC-15103 / HC / NHLBI NIH HHS / United States N01WH32111-13 / WH / WHI NIH HHS / United States N01WH32118-32119 / WH / WHI NIH HHS / United States U01HG004801 / HG / NHGRI NIH HHS / United States R37CA54281 / CA / NCI NIH HHS / United States N0142129-32 / / PHS HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States U01HG004790 / HG / NHGRI NIH HHS / United States U01 HG004798 / HG / NHGRI NIH HHS / United States HL080295 / HL / NHLBI NIH HHS / United States N01-HC-85239 / HC / NHLBI NIH HHS / United States N01-HC-48048 / HC / NHLBI NIH HHS / United States AG-023629 / AG / NIA NIH HHS / United States R01 HL109301 / HL / NHLBI NIH HHS / United States N01WH32115 / WH / WHI NIH HHS / United States P30 CA071789 / CA / NCI NIH HHS / United States P01CA33619 / CA / NCI NIH HHS / United States N01WH24152 / WH / WHI NIH HHS / United States R01 CA63 / CA / NCI NIH HHS / United States U01 HG004801 / HG / NHGRI NIH HHS / United States |