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Effect of dementia on the use of drugs for secondary prevention of ischemic heart disease.
Monday,2014-05-05 13:31 America/Los_Angeles — poolea2
| Title | Effect of dementia on the use of drugs for secondary prevention of ischemic heart disease. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Fowler, NR, Barnato, AE, Degenholtz, HB, Curcio, AM, Becker, JT, Kuller, LH, Lopez, OL |
| Journal | J Aging Res |
| Volume | 2014 |
| Pagination | 897671 |
| Date Published | 2014 |
| ISSN | 2090-2204 |
| Abstract | <p>Background. Dementia and cardiovascular disease (CVD) are frequently comorbid. The presence of dementia may have an effect on how CVD is treated. Objective. To examine the effect of dementia on the use of four medications recommended for secondary prevention of ischemic heart disease (IHD): angiotensin-converting enzyme inhibitors, beta-blockers, lipid-lowering medications, and antiplatelet medications. Design. Retrospective analysis of data from the Cardiovascular Health Study: Cognition Study. Setting and Subjects. 1,087 older adults in four US states who had or developed IHD between 1989 and 1998. Methods. Generalized estimating equations to explore the association between dementia and the use of guideline-recommended medications for the secondary prevention of IHD. Results. The length of follow-up for the cohort was 8.7 years and 265 (24%) had or developed dementia during the study. Use of medications for the secondary prevention of IHD for patients with and without dementia increased during the study period. In models, subjects with dementia were not less likely to use any one particular class of medication but were less likely to use two or more classes of medications as a group (OR, 0.60; 95% CI, 0.36-0.99). Conclusions. Subjects with dementia used fewer guideline-recommended medications for the secondary prevention of IHD than those without dementia. </p> |
| DOI | 10.1155/2014/897671 |
| Alternate Journal | J Aging Res |
| PubMed ID | 24719764 |
| PubMed Central ID | PMC3955600 |
| Grant List | UL1 TR000005 / TR / NCATS NIH HHS / United States R01 AG015928 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States R56 AG020098 / AG / NIA NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States K12 HS019461 / HS / AHRQ HHS / United States R01 HL080295 / HL / NHLBI NIH HHS / United States R01 AG020098 / AG / NIA NIH HHS / United States KL2 TR000146 / TR / NCATS NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States R01 AG027058 / AG / NIA NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States R56 AG023629 / AG / NIA NIH HHS / United States |