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Kidney function and cognitive health in older adults: the Cardiovascular Health Study.
Thursday,2014-05-29 14:04 America/Los_Angeles — poolea2
| Title | Kidney function and cognitive health in older adults: the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Darsie, B, Shlipak, MG, Sarnak, MJ, Katz, R, Fitzpatrick, AL, Odden, MC |
| Journal | Am J Epidemiol |
| Volume | 180 |
| Issue | 1 |
| Pagination | 68-75 |
| Date Published | 2014 Jul 01 |
| ISSN | 1476-6256 |
| Keywords | Aged, Cardiovascular Diseases, Cognition, Cognition Disorders, Cystatin C, Female, Glomerular Filtration Rate, Health Status, Humans, Kidney, Kidney Diseases, Male, Neuropsychological Tests |
| Abstract | <p>Recent evidence has demonstrated the importance of kidney function in healthy aging. We examined the association between kidney function and change in cognitive function in 3,907 participants in the Cardiovascular Health Study who were recruited from 4 US communities and studied from 1992 to 1999. Kidney function was measured by cystatin C-based estimated glomerular filtration rate (eGFRcys). Cognitive function was assessed using the Modified Mini-Mental State Examination and the Digit Symbol Substitution Test, which were administered up to 7 times during annual visits. There was an association between eGFRcys and change in cognitive function after adjustment for confounders; persons with an eGFRcys of less than 60 mL/minute/1.73 m(2) had a 0.64 (95% confidence interval: 0.51, 0.77) points/year faster decline in Modified Mini-Mental State Examination score and a 0.42 (95% confidence interval: 0.28, 0.56) points/year faster decline in Digit Symbol Substitution Test score compared with persons with an eGFRcys of 90 or more mL/minute/1.73 m(2). Additional adjustment for intermediate cardiovascular events modestly affected these associations. Participants with an eGFRcys of less than 60 mL/minute/1.73 m(2) had fewer cognitive impairment-free life-years on average compared with those with eGFRcys of 90 or more mL/minute/1.73 m(2), independent of confounders and mediating cardiovascular events (mean difference = -0.44, 95% confidence interval: -0.62, -0.26). Older adults with lower kidney function are at higher risk of worsening cognitive function. </p> |
| DOI | 10.1093/aje/kwu102 |
| Alternate Journal | Am. J. Epidemiol. |
| PubMed ID | 24844846 |
| PubMed Central ID | PMC4070934 |
| Grant List | N01HC55222 / HC / NHLBI NIH HHS / United States R01AG027002 / AG / NIA NIH HHS / United States N01HC85080 / HC / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States K01 AG039387 / AG / NIA NIH HHS / United States 268200800007C / / PHS HHS / United States 268201200036C / / PHS HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01HC85081 / HC / NHLBI NIH HHS / United States N01HC85079 / HC / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States N01HC85086 / HC / NHLBI NIH HHS / United States R01AG023629 / AG / NIA NIH HHS / United States R01 HL080295 / HL / NHLBI NIH HHS / United States N01HC85082 / HC / NHLBI NIH HHS / United States R01 AG027002 / AG / NIA NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States HL080295 / HL / NHLBI NIH HHS / United States N01HC85083 / HC / NHLBI NIH HHS / United States K01AG039387 / AG / NIA NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States |