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Lipoprotein-associated phospholipase A2 and risk of dementia in the Cardiovascular Health Study.
Monday,2014-06-16 13:07 America/Los_Angeles — poolea2
| Title | Lipoprotein-associated phospholipase A2 and risk of dementia in the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Fitzpatrick, AL, Irizarry, MC, Cushman, M, Jenny, NS, Chi, GC, Koro, C |
| Journal | Atherosclerosis |
| Volume | 235 |
| Issue | 2 |
| Pagination | 384-91 |
| Date Published | 2014 Aug |
| ISSN | 1879-1484 |
| Keywords | 1-Alkyl-2-acetylglycerophosphocholine Esterase, Aged, Alzheimer Disease, Dementia, Female, Humans, Male, Risk, Risk Factors |
| Abstract | <p><b>OBJECTIVE: </b>To evaluate associations between Lipoprotein-associated phospholipase A2 (Lp-PLA2) mass and activity with risk of dementia and its subtypes.</p><p><b>METHODS: </b>Analysis were completed on 3320 participants of the Cardiovascular Health Study (CHS), a population-based longitudinal study of community-dwelling adults age ≥65 years followed for an average of 5.4 years. Baseline serum Lp-PLA2 mass was measured using a sandwich enzyme immunoassay and Lp-PLA2 activity utilized a tritiated-platelet activating factor activity assay. Cox proportional hazards regression assessed the relative risk of incident dementia with higher baseline Lp-PLA2 adjusting for demographics, cardiovascular disease (CVD) and risk factors, inflammation markers and apolipoprotein E (APOE) genotype.</p><p><b>RESULTS: </b>Each standard deviation higher Lp-PLA2 mass and activity were related to increased risk of dementia (fully adjusted HR: 1.11 per SD, 95% CI: 1.00-1.24 for mass; HR: 1.12 per SD, 95% CI: 1.00-1.26 for activity). Persons in the highest quartile of Lp-PLA2 mass were 50% more likely to develop dementia than those in the lowest quartile in adjusted models (HR: 1.49; 95% CI: 1.08-2.06). Among dementia subtypes, the risk of AD was increased two-fold in the highest compared to lowest quartile of Lp-PLA2 mass (adjusted HR: 1.98, 95% CI: 1.22-3.21). Results were attenuated in models of mixed dementia and VaD. Lp-PLA2 activity also doubled the risk of mixed dementia in the highest compared to lowest quartile (HR: 2.21, 95% CI: 1.12-4.373).</p><p><b>INTERPRETATION: </b>These data support Lp-PLA2 as a risk factor for dementia independent of CVD and its risk factors. Further study is required to clarify the role of Lp-PLA2-related mechanisms in dementia subtypes.</p> |
| DOI | 10.1016/j.atherosclerosis.2014.04.032 |
| Alternate Journal | Atherosclerosis |
| PubMed ID | 24929287 |
| PubMed Central ID | PMC4096578 |
| Grant List | R01AG15928 / AG / NIA NIH HHS / United States R01 AG015928 / AG / NIA NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States AG023629 / AG / NIA NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States |