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Physical activity, body mass index, and brain atrophy in Alzheimer's disease.
Wednesday,2015-03-04 11:20 America/Los_Angeles — zdrager
| Title | Physical activity, body mass index, and brain atrophy in Alzheimer's disease. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Boyle, CP, Raji, CA, Erickson, KI, Lopez, OL, Becker, JT, H Gach, M, Longstreth, WT, Teverovskiy, L, Kuller, LH, Carmichael, OT, Thompson, PM |
| Journal | Neurobiol Aging |
| Volume | 36 Suppl 1 |
| Pagination | S194-S202 |
| Date Published | 2015 Jan |
| ISSN | 1558-1497 |
| Keywords | Aged, Aged, 80 and over, Aging, Alzheimer Disease, Atrophy, Biomarkers, Body Mass Index, Brain, Cognitive Dysfunction, Cross-Sectional Studies, Diffusion Magnetic Resonance Imaging, Female, Humans, Magnetic Resonance Imaging, Male, Motor Activity, Neuroimaging |
| Abstract | <p>The purpose of this study was to use a novel imaging biomarker to assess associations between physical activity (PA), body mass index (BMI), and brain structure in normal aging, mild cognitive impairment, and Alzheimer's dementia. We studied 963 participants (mean age: 74.1 ± 4.4 years) from the multisite Cardiovascular Health Study including healthy controls (n = 724), Alzheimer's dementia patients (n = 104), and people with mild cognitive impairment (n = 135). Volumetric brain images were processed using tensor-based morphometry to analyze regional brain volumes. We regressed the local brain tissue volume on reported PA and computed BMI, and performed conjunction analyses using both variables. Covariates included age, sex, and study site. PA was independently associated with greater whole brain and regional brain volumes and reduced ventricular dilation. People with higher BMI had lower whole brain and regional brain volumes. A PA-BMI conjunction analysis showed brain preservation with PA and volume loss with increased BMI in overlapping brain regions. In one of the largest voxel-based cross-sectional studies to date, PA and lower BMI may be beneficial to the brain across the spectrum of aging and neurodegeneration. </p> |
| DOI | 10.1016/j.neurobiolaging.2014.05.036 |
| Alternate Journal | Neurobiol. Aging |
| PubMed ID | 25248607 |
| PubMed Central ID | PMC4303036 |
| Grant List | AG15928 / AG / NIA NIH HHS / United States RF1 AG041915 / AG / NIA NIH HHS / United States N01-HC-80007 / HC / NHLBI NIH HHS / United States R01 AG015928 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States R01 AG040060 / AG / NIA NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States AG020098 / AG / NIA NIH HHS / United States R56 AG020098 / AG / NIA NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States U54 EB020403 / EB / NIBIB NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States AG05133 / AG / NIA NIH HHS / United States N01-HC-055222 / HC / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States P50 AG005133 / AG / NIA NIH HHS / United States EB008281 / EB / NIBIB NIH HHS / United States R01 AG020098 / AG / NIA NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States R01 EB008281 / EB / NIBIB NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01 HC085079 / HC / NHLBI NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States |