You are here
Variation in resting heart rate over 4 years and the risks of myocardial infarction and death among older adults.
Wednesday,2015-03-04 12:26 America/Los_Angeles — zdrager
| Title | Variation in resting heart rate over 4 years and the risks of myocardial infarction and death among older adults. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Floyd, JS, Sitlani, CM, Wiggins, KL, Wallace, E, Suchy-Dicey, A, Abbasi, SA, Carnethon, MR, Siscovick, DS, Sotoodehnia, N, Heckbert, SR, McKnight, B, Rice, KM, Psaty, BM |
| Journal | Heart |
| Volume | 101 |
| Issue | 2 |
| Pagination | 132-8 |
| Date Published | 2015 Jan |
| ISSN | 1468-201X |
| Keywords | Aged, Aged, 80 and over, Cause of Death, Electrocardiography, Female, Follow-Up Studies, Heart Rate, Humans, Incidence, Linear Models, Male, Myocardial Infarction, Outcome Assessment (Health Care), Prognosis, Proportional Hazards Models, Prospective Studies, Rest, Risk Factors, Time, Washington |
| Abstract | <p><b>OBJECTIVE: </b>Resting heart rate (RHR) is an established predictor of myocardial infarction (MI) and mortality, but the relationship between variation in RHR over a period of several years and health outcomes is unclear. We evaluated the relationship between long-term variation in RHR and the risks of incident MI and mortality among older adults.</p><p><b>METHODS: </b>1991 subjects without cardiovascular disease from the Cardiovascular Health Study were included. RHR was taken from resting ECGs at the first five annual study visits. RHR mean, trend and variation were estimated with linear regression. Subjects were followed for incident MI and death until December 2010. HRs for RHR mean, trend and variation are reported for differences of 10 bpm, 2 bpm/year and 2 bpm, respectively.</p><p><b>RESULTS: </b>262 subjects had an incident MI event (13%) and 1326 died (67%) during 12 years of median follow-up. In primary analyses adjusted for cardiovascular risk factors, RHR mean (HR 1.12; 95% CI 1.05 to 1.20) and variation (HR 1.08; 95% CI 1.03 to 1.13) were associated with the risk of death while trend was not. None of the RHR variables were significantly associated with the risk of incident MI events; however, CIs were wide and the MI associations with RHR variables were not significantly different from the mortality associations. Adjusting for additional variables did not affect estimates, and there were no significant interactions with sex.</p><p><b>CONCLUSIONS: </b>Variation in RHR over a period of several years represents a potential predictor of long-term mortality among older persons free of cardiovascular disease.</p> |
| DOI | 10.1136/heartjnl-2014-306046 |
| Alternate Journal | Heart |
| PubMed ID | 25214500 |
| PubMed Central ID | PMC4286483 |
| Grant List | N01HC55222 / HC / NHLBI NIH HHS / United States N01HC85080 / HC / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States K08 HL116640 / HL / NHLBI NIH HHS / United States N01HC85081 / HC / NHLBI NIH HHS / United States N01HC85079 / HC / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States K08HL116640 / HL / NHLBI NIH HHS / United States N01HC85086 / HC / NHLBI NIH HHS / United States N01HC85082 / HC / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85083 / HC / NHLBI NIH HHS / United States U01HL080295 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States AG023629 / AG / NIA NIH HHS / United States R56 AG023629 / AG / NIA NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States |