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Circulating and dietary trans fatty acids and incident type 2 diabetes in older adults: the Cardiovascular Health Study.
Tuesday,2015-04-07 12:51 America/Los_Angeles — zdrager
| Title | Circulating and dietary trans fatty acids and incident type 2 diabetes in older adults: the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Wang, Q, Imamura, F, Ma, W, Wang, M, Lemaitre, RN, King, IB, Song, X, Biggs, ML, Delaney, JA, Mukamal, KJ, Djoussé, L, Siscovick, DS, Mozaffarian, D |
| Journal | Diabetes Care |
| Volume | 38 |
| Issue | 6 |
| Pagination | 1099-107 |
| Date Published | 2015 Jun |
| ISSN | 1935-5548 |
| Keywords | Aged, Biomarkers, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Dietary Fats, Unsaturated, Epidemiologic Methods, Female, Food Habits, Humans, Male, Phospholipids, Trans Fatty Acids |
| Abstract | <p><b>OBJECTIVE: </b>To investigate the effects of trans fatty acids (TFAs) on type 2 diabetes mellitus (DM) by specific TFA subtype or method of assessment.</p><p><b>RESEARCH DESIGN AND METHODS: </b>In the Cardiovascular Health Study, plasma phospholipid trans (t)-16:1n9, t-18:1, and cis (c)/t-, t/c-, and t/t-18:2 were measured in blood drawn from 2,919 adults aged 74 ± 5 years and free of prevalent DM in 1992. Dietary TFA was estimated among 4,207 adults free of prevalent DM when dietary questionnaires were initially administered in 1989 or 1996. Incident DM was defined through 2010 by medication use or blood glucose levels. Risks were assessed by Cox proportional hazards.</p><p><b>RESULTS: </b>In biomarker analyses, 287 DM cases occurred during 30,825 person-years. Both t-16:1n9 (extreme quartile hazard ratio 1.59 [95% CI 1.04-2.42], P-trend = 0.04) and t-18:1 (1.91 [1.20-3.03], P-trend = 0.01) levels were associated with higher incident DM after adjustment for de novo lipogenesis fatty acids. In dietary analyses, 407 DM cases occurred during 50,105 person-years. Incident DM was positively associated with consumption of total TFAs (1.38 [1.03-1.86], P-trend = 0.02), t-18:1 (1.32 [1.00-1.76], P-trend = 0.04), and t-18:2 (1.41 [1.05-1.89], P-trend = 0.02). After further adjustment for other dietary habits, however, the associations of estimated dietary TFA with DM were attenuated, and only nonsignificant positive trends remained.</p><p><b>CONCLUSIONS: </b>Among older adults, plasma phospholipid t-16:1n9 and t-18:1 levels were positively related to DM after adjustment for de novo lipogenesis fatty acids. Estimated dietary TFA was not significantly associated with DM. These findings highlight the need for further observational, interventional, and experimental studies of the effects TFA on DM.</p> |
| DOI | 10.2337/dc14-2101 |
| Alternate Journal | Diabetes Care |
| PubMed ID | 25784660 |
| PubMed Central ID | PMC4439533 |
| Grant List | 2R01-HL-085710 / HL / NHLBI NIH HHS / United States AG-023629 / AG / NIA NIH HHS / United States HHSN268200800007C / / PHS HHS / United States HHSN268201200036C / / PHS HHS / United States HL-080295 / HL / NHLBI NIH HHS / United States MC_UP_A100_1003 / / Medical Research Council / United Kingdom MC_UU_12015/5 / / Medical Research Council / United Kingdom N01-HC-55222 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85080 / HC / NHLBI NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States N01-HC-85082 / HC / NHLBI NIH HHS / United States N01-HC-85083 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States R01 HL085710 / HL / NHLBI NIH HHS / United States R01-HL-085710 / HL / NHLBI NIH HHS / United States R01-HL-094555 / HL / NHLBI NIH HHS / United States |