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Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium.

Friday,2015-04-17 14:15 America/Los_Angeles — zdrager
TitleDietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium.
Publication TypeJournal Article
Year of Publication2015
AuthorsSmith, CE, Follis, JL, Nettleton, JA, Foy, M, H Y Wu, J, Ma, Y, Tanaka, T, Manichakul, AW, Wu, H, Chu, AY, Steffen, LM, Fornage, M, Mozaffarian, D, Kabagambe, EK, Ferruci, L, Chen, Y-DI, Rich, SS, Djoussé, L, Ridker, PM, Tang, W, McKnight, B, Tsai, MY, Bandinelli, S, Rotter, JI, Hu, FB, Chasman, DI, Psaty, BM, Arnett, DK, King, IB, Sun, Q, Wang, L, Lumley, T, Chiuve, SE, Siscovick, DS, Ordovas, JM, Lemaitre, RN
JournalMol Nutr Food Res
Volume59
Issue7
Pagination1373-83
Date Published2015 Jul
ISSN1613-4133
KeywordsAcetyltransferases, Acyltransferases, Adaptor Proteins, Signal Transducing, Carboxy-Lyases, Diet, Docosahexaenoic Acids, Eicosapentaenoic Acid, Erythrocyte Membrane, Fatty Acid Desaturases, Fatty Acids, Fatty Acids, Omega-3, Female, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide
Abstract<p><b>SCOPE: </b>Tissue concentrations of omega-3 fatty acids may reduce cardiovascular disease risk, and genetic variants are associated with circulating fatty acids concentrations. Whether dietary fatty acids interact with genetic variants to modify circulating omega-3 fatty acids is unclear. We evaluated interactions between genetic variants and fatty acid intakes for circulating alpha-linoleic acid, eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid.</p><p><b>METHODS AND RESULTS: </b>We conducted meta-analyses (N = 11 668) evaluating interactions between dietary fatty acids and genetic variants (rs174538 and rs174548 in FADS1 (fatty acid desaturase 1), rs7435 in AGPAT3 (1-acyl-sn-glycerol-3-phosphate), rs4985167 in PDXDC1 (pyridoxal-dependent decarboxylase domain-containing 1), rs780094 in GCKR (glucokinase regulatory protein), and rs3734398 in ELOVL2 (fatty acid elongase 2)). Stratification by measurement compartment (plasma versus erthyrocyte) revealed compartment-specific interactions between FADS1 rs174538 and rs174548 and dietary alpha-linolenic acid and linoleic acid for docosahexaenoic acid and docosapentaenoic acid.</p><p><b>CONCLUSION: </b>Our findings reinforce earlier reports that genetically based differences in circulating fatty acids may be partially due to differences in the conversion of fatty acid precursors. Further, fatty acids measurement compartment may modify gene-diet relationships, and considering compartment may improve the detection of gene-fatty acids interactions for circulating fatty acid outcomes.</p>
DOI10.1002/mnfr.201400734
Alternate JournalMol Nutr Food Res
PubMed ID25626431
PubMed Central IDPMC4491005
Grant ListAG023629 / AG / NIA NIH HHS / United States
CA047988 / CA / NCI NIH HHS / United States
CA055075 / CA / NCI NIH HHS / United States
DK063491 / DK / NIDDK NIH HHS / United States
HHSN268200800007C / / PHS HHS / United States
HHSN268200900041C / / PHS HHS / United States
HHSN268201100005C / / PHS HHS / United States
HHSN268201100006C / / PHS HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100009C / / PHS HHS / United States
HHSN268201100010C / / PHS HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100012C / / PHS HHS / United States
HHSN268201200036C / / PHS HHS / United States
HHSN268201300025C / / PHS HHS / United States
HHSN268201300026C / / PHS HHS / United States
HHSN268201300027C / / PHS HHS / United States
HHSN268201300028C / / PHS HHS / United States
HHSN268201300029C / / PHS HHS / United States
HL043851 / HL / NHLBI NIH HHS / United States
HL078885 / HL / NHLBI NIH HHS / United States
HL080295 / HL / NHLBI NIH HHS / United States
HL080467 / HL / NHLBI NIH HHS / United States
HL085710 / HL / NHLBI NIH HHS / United States
HL087652 / HL / NHLBI NIH HHS / United States
HL099355 / HL / NHLBI NIH HHS / United States
HL105756 / HL / NHLBI NIH HHS / United States
HL54776 / HL / NHLBI NIH HHS / United States
HL60712 / HL / NHLBI NIH HHS / United States
HSN268200625226C / / PHS HHS / United States
K08 HL112845 / HL / NHLBI NIH HHS / United States
K08 HL112845 / HL / NHLBI NIH HHS / United States
N01-HC-95159 / HC / NHLBI NIH HHS / United States
N01-HC-95160 / HC / NHLBI NIH HHS / United States
N01-HC-95161 / HC / NHLBI NIH HHS / United States
N01-HC-95162 / HC / NHLBI NIH HHS / United States
N01-HC-95163 / HC / NHLBI NIH HHS / United States
N01-HC-95164 / HC / NHLBI NIH HHS / United States
N01-HC-95165 / HC / NHLBI NIH HHS / United States
N01-HC-95166 / HC / NHLBI NIH HHS / United States
N01-HC-95167 / HC / NHLBI NIH HHS / United States
N01-HC-95168 / HC / NHLBI NIH HHS / United States
N01-HC-95169 / HC / NHLBI NIH HHS / United States
N01HC55222 / HC / NHLBI NIH HHS / United States
N01HC85079 / HC / NHLBI NIH HHS / United States
N01HC85080 / HC / NHLBI NIH HHS / United States
N01HC85081 / HC / NHLBI NIH HHS / United States
N01HC85082 / HC / NHLBI NIH HHS / United States
N01HC85083 / HC / NHLBI NIH HHS / United States
N01HC85086 / HC / NHLBI NIH HHS / United States
N02HL64278 / HL / NHLBI NIH HHS / United States
P01 CA87969 / CA / NCI NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
R00 HL097068 / HL / NHLBI NIH HHS / United States
R00-HL095649 / HL / NHLBI NIH HHS / United States
R00HL098459 / HL / NHLBI NIH HHS / United States
R01 HL034594 / HL / NHLBI NIH HHS / United States
R01 HL085710 / HL / NHLBI NIH HHS / United States
R01 HL091357 / HL / NHLBI NIH HHS / United States
R01 HL35464 / HL / NHLBI NIH HHS / United States
R01-HL-084099 / HL / NHLBI NIH HHS / United States
R01HL086694 / HL / NHLBI NIH HHS / United States
R01HL087641 / HL / NHLBI NIH HHS / United States
R01HL59367 / HL / NHLBI NIH HHS / United States
RR-024156 / RR / NCRR NIH HHS / United States
U01-HG-004424 / HG / NHGRI NIH HHS / United States
U01-HG-004446 / HG / NHGRI NIH HHS / United States
U01-HG-004729 / HG / NHGRI NIH HHS / United States
U01HG004402 / HG / NHGRI NIH HHS / United States
U01HL072524 / HL / NHLBI NIH HHS / United States
UL1 TR000124 / TR / NCATS NIH HHS / United States
UL1RR025005 / RR / NCRR NIH HHS / United States
UL1TR000124 / TR / NCATS NIH HHS / United States
UM1 CA167552 / CA / NCI NIH HHS / United States
UM1 CA182913 / CA / NCI NIH HHS / United States
/ / Intramural NIH HHS / United States

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