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Genetic diversity is a predictor of mortality in humans.

TitleGenetic diversity is a predictor of mortality in humans.
Publication TypeJournal Article
Year of Publication2014
AuthorsBihlmeyer, NA, Brody, JA, Smith, AVernon, Lunetta, KL, Nalls, M, Smith, JA, Tanaka, T, Davies, G, Yu, L, Mirza, SSaeed, Teumer, A, Coresh, J, Pankow, JS, Franceschini, N, Scaria, A, Oshima, J, Psaty, BM, Gudnason, V, Eiriksdottir, G, Harris, TB, Li, H, Karasik, D, Kiel, DP, Garcia, M, Liu, Y, Faul, JD, Kardia, SLr, Zhao, W, Ferrucci, L, Allerhand, M, Liewald, DC, Redmond, P, Starr, JM, De Jager, PL, Evans, DA, Direk, N, Ikram, MArfan, Uitterlinden, A, Homuth, G, Lorbeer, R, Grabe, HJ, Launer, L, Murabito, JM, Singleton, AB, Weir, DR, Bandinelli, S, Deary, IJ, Bennett, DA, Tiemeier, H, Kocher, T, Lumley, T, Arking, DE
JournalBMC Genet
Date Published2014
KeywordsGenome-Wide Association Study, Heterozygote, Humans, Mortality, Polymorphism, Single Nucleotide, Proportional Hazards Models
Abstract<p><b>BACKGROUND: </b>It has been well-established, both by population genetics theory and direct observation in many organisms, that increased genetic diversity provides a survival advantage. However, given the limitations of both sample size and genome-wide metrics, this hypothesis has not been comprehensively tested in human populations. Moreover, the presence of numerous segregating small effect alleles that influence traits that directly impact health directly raises the question as to whether global measures of genomic variation are themselves associated with human health and disease.</p><p><b>RESULTS: </b>We performed a meta-analysis of 17 cohorts followed prospectively, with a combined sample size of 46,716 individuals, including a total of 15,234 deaths. We find a significant association between increased heterozygosity and survival (P = 0.03). We estimate that within a single population, every standard deviation of heterozygosity an individual has over the mean decreases that person's risk of death by 1.57%.</p><p><b>CONCLUSIONS: </b>This effect was consistent between European and African ancestry cohorts, men and women, and major causes of death (cancer and cardiovascular disease), demonstrating the broad positive impact of genomic diversity on human survival.</p>
Alternate JournalBMC Genet.
PubMed ID25543667
PubMed Central IDPMC4301661
Grant List5T32GM07814 / GM / NIGMS NIH HHS / United States
P30 AG010161 / AG / NIA NIH HHS / United States
R01 AG017917 / AG / NIA NIH HHS / United States
R24 AG042328 / AG / NIA NIH HHS / United States
RF1 AG015819 / AG / NIA NIH HHS / United States
U01 AG009740 / AG / NIA NIH HHS / United States