You are here
Changes in insulin-like growth factor-I and its binding proteins are associated with diabetes mellitus in older adults.
Monday,2015-06-15 13:55 America/Los_Angeles — zdrager
| Title | Changes in insulin-like growth factor-I and its binding proteins are associated with diabetes mellitus in older adults. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Aneke-Nash, CS, Parrinello, CM, Rajpathak, SN, Rohan, TE, Strotmeyer, ES, Kritchevsky, SB, Psaty, BM, Bůzková, P, Kizer, JR, Newman, AB, Strickler, HD, Kaplan, RC |
| Journal | J Am Geriatr Soc |
| Volume | 63 |
| Issue | 5 |
| Pagination | 902-9 |
| Date Published | 2015 May |
| ISSN | 1532-5415 |
| Keywords | Aged, Blood Glucose, Cohort Studies, Diabetes Mellitus, Type 2, Female, Humans, Insulin-Like Growth Factor Binding Protein 1, Insulin-Like Growth Factor Binding Protein 3, Insulin-Like Growth Factor I, Male, Retrospective Studies |
| Abstract | <p><b>OBJECTIVES: </b>To determine whether changes in insulin-like growth factor (IGF) protein levels are greater in participants with type 2 diabetes mellitus or worsening glycemia than in normoglycemic individuals over a 9-year follow-up period.</p><p><b>DESIGN: </b>Retrospective analysis of a cohort study.</p><p><b>SETTING: </b>Participants were recruited from North Carolina, California, Maryland, and Pennsylvania.</p><p><b>PARTICIPANTS: </b>Cardiovascular Health Study All Stars participants, a cohort study of community-dwelling adults aged 65 and older (N=897).</p><p><b>MEASUREMENTS: </b>Plasma IGF-I, IGF binding protein (IGFBP)-1, and IGFBP-3 levels were assessed and American Diabetes Association cut-points for impaired glucose tolerance (IGT), impaired fasting glucose (IFG), and diabetes mellitus were used to classify participants at baseline (1996-97) and follow-up (2005-06).</p><p><b>RESULTS: </b>At baseline, mean age was 76.3±3.6, and 18.5% had diabetes mellitus. Participants with IFG alone and IGT plus IFG had higher IGF-I levels and lower IGFBP-1 levels than those with normoglycemia or diabetes mellitus. The greatest percentage change in IGF levels occurred in those who had diabetes mellitus at baseline (9-year changes: -9.3% for IGF-I, 59.7% for IGFBP-1, -13.4% for IGFBP-3), the smallest in individuals who remained normoglycemic at follow-up (9-year changes: -3.7% for IGF-I, 25.6% for IGFBP-1, -6.4% for IGFBP-3), and intermediate in those who were normoglycemic but developed IFG at follow-up.</p><p><b>CONCLUSION: </b>Degrees of glycemic impairment are associated with varying degrees of change in IGF protein levels. The changes observed in the diabetes mellitus group have been previously shown to be associated with heart failure, cancer, and noncancer mortality.</p> |
| DOI | 10.1111/jgs.13390 |
| Alternate Journal | J Am Geriatr Soc |
| PubMed ID | 25989565 |
| PubMed Central ID | PMC4438274 |
| Grant List | AG023629 / AG / NIA NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States HHSN268201200036C / / PHS HHS / United States HL080295 / HL / NHLBI NIH HHS / United States KL2 TR000088 / TR / NCATS NIH HHS / United States N01 HC55222 / HC / NHLBI NIH HHS / United States N01HC-85081 / HC / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85079 / HC / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01HC85080 / HC / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States N01HC85082 / HC / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HC / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85086 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01HC85239 / HC / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States R01 HL080295 / HL / NHLBI NIH HHS / United States R56 AG023629 / AG / NIA NIH HHS / United States T32 GM007288 / GM / NIGMS NIH HHS / United States T32-GM007288 / GM / NIGMS NIH HHS / United States TL1 TR001072 / TR / NCATS NIH HHS / United States TL1RR000087 / RR / NCRR NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States UL1 TR000086 / TR / NCATS NIH HHS / United States UL1TR000086 / TR / NCATS NIH HHS / United States |