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Physical Activity, Physical Fitness, and Leukocyte Telomere Length: The Cardiovascular Health Study.
Monday,2015-06-22 09:45 America/Los_Angeles — zdrager
| Title | Physical Activity, Physical Fitness, and Leukocyte Telomere Length: The Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Soares-Miranda, L, Imamura, F, Siscovick, D, Jenny, NSwords, Fitzpatrick, AL, Mozaffarian, D |
| Journal | Med Sci Sports Exerc |
| Volume | 47 |
| Issue | 12 |
| Pagination | 2525-34 |
| Date Published | 2015 Dec |
| ISSN | 1530-0315 |
| Keywords | Aged, Aging, Cross-Sectional Studies, Exercise Test, Female, Hand Strength, Humans, Leukocytes, Male, Motor Activity, Physical Fitness, Prospective Studies, Telomere Homeostasis, Walking |
| Abstract | <p><b>INTRODUCTION: </b>The influence of physical activity (PA) and physical fitness (PF) at older ages on changes in telomere length (TL)--repetitive DNA sequences that may mark biologic aging--is not well-established. Few prior studies (mainly cross-sectional) have been conducted in older adults, and few studies have evaluated PF.</p><p><b>METHODS: </b>We investigated cross-sectional and prospective associations of PA and PF with leukocyte TL among 582 older adults (mean ± SD age, 73 ± 5 yr at baseline) in the Cardiovascular Health Study, with serial TL measures and PA and PF assessed multiple times. Cross-sectional associations were assessed using multivariable repeated-measures regression, in which cumulatively averaged PA and PF measures were related to TL. Longitudinal analyses assessed cumulatively averaged PA and PF against later changes in TL, and changes in cumulatively averaged PA and PF against changes in TL.</p><p><b>RESULTS: </b>Cross-sectionally, greater walking distance and chair test performance, but not other PA and PF measures, were each associated with longer TL (P trend = 0.007 and 0.04, respectively). In longitudinal analyses, no significant associations of baseline PA and PF with change in TL were observed. In contrast, changes in leisure-time activity and chair test performance were each inversely associated with changes in TL.</p><p><b>CONCLUSIONS: </b>Cross-sectional analyses suggest that greater PA and PF are associated with longer TL. Prospective analyses show that changes in PA and PF are associated with differences in changes in TL. Even later in life, changes in certain PA and PF measures are associated with changes in TL, suggesting that leisure-time activity and fitness could reduce leukocyte telomere attrition among older adults.</p> |
| DOI | 10.1249/MSS.0000000000000720 |
| Alternate Journal | Med Sci Sports Exerc |
| PubMed ID | 26083773 |
| PubMed Central ID | PMC4648672 |
| Grant List | HHSN268200800007C / HL / NHLBI NIH HHS / United States HHSN268200800007C / / PHS HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States HHSN268201200036C / / PHS HHS / United States MC_UP_A100_1003 / / Medical Research Council / United Kingdom MC_UU_12015/5 / / Medical Research Council / United Kingdom MC_UU_12015/5 / / Medical Research Council / United Kingdom N01HC55222 / HC / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85079 / HC / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01HC85080 / HC / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85081 / HC / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States N01HC85082 / HC / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HC / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85086 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States R01AG023629 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States U01HL080295 / HL / NHLBI NIH HHS / United States |
ePub date:
2015 Jun 16