You are here
Genome-wide meta-analyses of smoking behaviors in African Americans.
Friday,2015-08-28 10:55 America/Los_Angeles — zdrager
| Title | Genome-wide meta-analyses of smoking behaviors in African Americans. |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | David, SP, Hamidovic, A, Chen, GK, Bergen, AW, Wessel, J, Kasberger, JL, Brown, WM, Petruzella, S, Thacker, EL, Kim, Y, Nalls, MA, Tranah, GJ, Sung, YJ, Ambrosone, CB, Arnett, D, Bandera, EV, Becker, DM, Becker, L, Berndt, SI, Bernstein, L, Blot, WJ, Broeckel, U, Buxbaum, SG, Caporaso, N, Casey, G, Chanock, SJ, Deming, SL, Diver, WR, Eaton, CB, Evans, DS, Evans, MK, Fornage, M, Franceschini, N, Harris, TB, Henderson, BE, Hernandez, DG, Hitsman, B, Hu, JJ, Hunt, SC, Ingles, SA, John, EM, Kittles, R, Kolb, S, Kolonel, LN, Le Marchand, L, Liu, Y, Lohman, KK, McKnight, B, Millikan, RC, Murphy, A, Neslund-Dudas, C, Nyante, S, Press, M, Psaty, BM, Rao, DC, Redline, S, Rodriguez-Gil, JL, Rybicki, BA, Signorello, LB, Singleton, AB, Smoller, J, Snively, B, Spring, B, Stanford, JL, Strom, SS, Swan, GE, Taylor, KD, Thun, MJ, Wilson, AF, Witte, JS, Yamamura, Y, Yanek, LR, Yu, K, Zheng, W, Ziegler, RG, Zonderman, AB, Jorgenson, E, Haiman, CA, Furberg, H |
| Journal | Transl Psychiatry |
| Volume | 2 |
| Pagination | e119 |
| Date Published | 2012 |
| ISSN | 2158-3188 |
| Keywords | Adult, African Americans, Aged, Chromosomes, Human, Pair 10, Chromosomes, Human, Pair 15, Female, Genetic Loci, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, Nerve Tissue Proteins, Phenotype, Polymorphism, Single Nucleotide, Proteoglycans, Receptors, Nicotinic, Smoking, Statistics as Topic |
| Abstract | <p>The identification and exploration of genetic loci that influence smoking behaviors have been conducted primarily in populations of the European ancestry. Here we report results of the first genome-wide association study meta-analysis of smoking behavior in African Americans in the Study of Tobacco in Minority Populations Genetics Consortium (n = 32,389). We identified one non-coding single-nucleotide polymorphism (SNP; rs2036527[A]) on chromosome 15q25.1 associated with smoking quantity (cigarettes per day), which exceeded genome-wide significance (β = 0.040, s.e. = 0.007, P = 1.84 × 10(-8)). This variant is present in the 5'-distal enhancer region of the CHRNA5 gene and defines the primary index signal reported in studies of the European ancestry. No other SNP reached genome-wide significance for smoking initiation (SI, ever vs never smoking), age of SI, or smoking cessation (SC, former vs current smoking). Informative associations that approached genome-wide significance included three modestly correlated variants, at 15q25.1 within PSMA4, CHRNA5 and CHRNA3 for smoking quantity, which are associated with a second signal previously reported in studies in European ancestry populations, and a signal represented by three SNPs in the SPOCK2 gene on chr10q22.1. The association at 15q25.1 confirms this region as an important susceptibility locus for smoking quantity in men and women of African ancestry. Larger studies will be needed to validate the suggestive loci that did not reach genome-wide significance and further elucidate the contribution of genetic variation to disparities in cigarette consumption, SC and smoking-attributable disease between African Americans and European Americans.</p> |
| DOI | 10.1038/tp.2012.41 |
| Alternate Journal | Transl Psychiatry |
| PubMed ID | 22832964 |
| PubMed Central ID | PMC3365260 |
| Grant List | N01 WH022110 / WH / WHI NIH HHS / United States N01 WH032105 / WH / WHI NIH HHS / United States N01 WH032108 / WH / WHI NIH HHS / United States N01 WH032109 / WH / WHI NIH HHS / United States N01 WH032111 / WH / WHI NIH HHS / United States N01 WH32115 / WH / WHI NIH HHS / United States P20 MD006899 / MD / NIMHD NIH HHS / United States P30 CA015704 / CA / NCI NIH HHS / United States P30 ES010126 / ES / NIEHS NIH HHS / United States P50 CA058223 / CA / NCI NIH HHS / United States R01 CA092447 / CA / NCI NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States R21 DA027331 / DA / NIDA NIH HHS / United States U01 DA020830 / DA / NIDA NIH HHS / United States UL1 RR025741 / RR / NCRR NIH HHS / United States UL1 TR000124 / TR / NCATS NIH HHS / United States UL1 TR000150 / TR / NCATS NIH HHS / United States |