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Positive association of tomato consumption with serum urate: support for tomato consumption as an anecdotal trigger of gout flares.
Friday,2015-08-28 14:36 America/Los_Angeles — zdrager
| Title | Positive association of tomato consumption with serum urate: support for tomato consumption as an anecdotal trigger of gout flares. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Flynn, TJ, Cadzow, M, Dalbeth, N, Jones, PB, Stamp, LK, Hindmarsh, JHarré, Todd, AS, Walker, RJ, Topless, R, Merriman, TR |
| Journal | BMC Musculoskelet Disord |
| Volume | 16 |
| Pagination | 196 |
| Date Published | 2015 |
| ISSN | 1471-2474 |
| Keywords | Adolescent, Adult, Aged, European Continental Ancestry Group, Female, Gout, Humans, Hyperuricemia, Lycopersicon esculentum, Male, Middle Aged, New Zealand, Oceanic Ancestry Group, Surveys and Questionnaires, Uric Acid, Young Adult |
| Abstract | <p><b>BACKGROUND: </b>Gout is a consequence of an innate immune reaction to monosodium urate crystals deposited in joints. Acute gout attacks can be triggered by dietary factors that are themselves associated with serum urate levels. Tomato consumption is an anecdotal trigger of gout flares. This study aimed to measure the frequency of tomato consumption as a self-reported trigger of gout attacks in a large New Zealand sample set, and to test the hypothesis that tomato consumption is associated with serum urate levels.</p><p><b>METHODS: </b>Two thousand fifty one New Zealanders (of Māori, Pacific Island, European or other ancestry) with clinically-ascertained gout were asked about gout trigger foods. European individuals from the Atherosclerosis Risk In Communities (ARIC; n = 7517) Study, Cardiovascular Health Study (CHS; n = 2151) and Framingham Heart Study (FHS; n = 3052) were used to test, in multivariate-adjusted analyses, for association between serum urate and tomato intake.</p><p><b>RESULTS: </b>Seventy one percent of people with gout reported having ≥1 gout trigger food. Of these 20% specifically mentioned tomatoes, the 4(th) most commonly reported trigger food. There was association between tomato intake and serum urate levels in the ARIC, CHS and FHS combined cohort (β = 0.66 μmolL(-1) increase in serum urate per additional serve per week; P = 0.006) - evident in both sexes (men: β = 0.84 μmolL(-1), P = 0.035; women: β = 0.59 μmolL (-1), P = 0.041).</p><p><b>CONCLUSIONS: </b>While our descriptive and observational data are unable to support the claim that tomato consumption is a trigger of gout attacks, the positive association between tomato consumption and serum urate levels suggests that the self-reporting of tomatoes as a dietary trigger by people with gout has a biological basis.</p> |
| DOI | 10.1186/s12891-015-0661-8 |
| Alternate Journal | BMC Musculoskelet Disord |
| PubMed ID | 26286027 |
| PubMed Central ID | PMC4541734 |
| Grant List | HHSN268200625226C / / PHS HHS / United States HHSN268201200036C / / PHS HHS / United States N01 HC-15103 / HC / NHLBI NIH HHS / United States N01 HC-55016 / HC / NHLBI NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States N01-HC-25195 / HC / NHLBI NIH HHS / United States N01-HC-35129 / HC / NHLBI NIH HHS / United States N01-HC-45133 / HC / NHLBI NIH HHS / United States N01-HC-55015 / HC / NHLBI NIH HHS / United States N01-HC-55018 / HC / NHLBI NIH HHS / United States N01-HC-55019 / HC / NHLBI NIH HHS / United States N01-HC-55020 / HC / NHLBI NIH HHS / United States N01-HC-55021 / HC / NHLBI NIH HHS / United States N01-HC-55022 / HC / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85080 / HC / NHLBI NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States N01-HC-85082 / HC / NHLBI NIH HHS / United States N01-HC-85083 / HC / NHLBI NIH HHS / United States N01-HC-85084 / HC / NHLBI NIH HHS / United States N01-HC-85085 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01-HC-85239 / HC / NHLBI NIH HHS / United States R01 AG-023629 / AG / NIA NIH HHS / United States R01 HL086694 / HL / NHLBI NIH HHS / United States R01 HL087641 / HL / NHLBI NIH HHS / United States R01 HL59367 / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States U01HG004402 / HG / NHGRI NIH HHS / United States |