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Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health Study.
Tuesday,2012-11-06 12:05 America/Los_Angeles — eenright
| Title | Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2002 |
| Authors | Young, T, Shahar, E, F Nieto, J, Redline, S, Newman, AB, Gottlieb, DJ, Walsleben, JA, Finn, L, Enright, P, Samet, JM |
| Corporate/Institutional Authors | Sleep Heart Health Study Research Group, |
| Journal | Arch Intern Med |
| Volume | 162 |
| Issue | 8 |
| Pagination | 893-900 |
| Date Published | 2002 Apr 22 |
| ISSN | 0003-9926 |
| Keywords | Adult, Age Factors, Aged, Aged, 80 and over, Cohort Studies, Continental Population Groups, Female, Humans, Male, Middle Aged, Obesity, Predictive Value of Tests, Residence Characteristics, Risk Factors, Sex Factors, Sleep Apnea Syndromes, Snoring |
| Abstract | <p><b>BACKGROUND: </b>Sleep-disordered breathing (SDB) is common, but largely undiagnosed in the general population. Information on demographic patterns of SDB occurrence and its predictive factors in the general population is needed to target high-risk groups that may benefit from diagnosis.</p><p><b>METHODS: </b>The sample comprised 5615 community-dwelling men and women aged between 40 and 98 years who were enrolled in the Sleep Heart Health Study. Data were collected by questionnaire, clinical examinations, and in-home polysomnography. Sleep-disordered breathing status was based on the average number of apnea and hypopnea episodes per hour of sleep (apnea-hypopnea index [AHI]). We used multiple logistic regression modeling to estimate cross-sectional associations of selected participant characteristics with SDB defined by an AHI of 15 or greater.</p><p><b>RESULTS: </b>Male sex, age, body mass index, neck girth, snoring, and repeated breathing pause frequency were independent, significant correlates of an AHI of 15 or greater. People reporting habitual snoring, loud snoring, and frequent breathing pauses were 3 to 4 times more likely to have an AHI of 15 or greater vs an AHI less than 15, but there were weaker associations for other factors with an AHI of 15 or greater. The odds ratios (95% confidence interval) for an AHI of 15 or greater vs an AHI less than 15 were 1.6 and 1.5, respectively, for 1-SD increments in body mass index and neck girth. As age increased, the magnitude of associations for SDB and body habitus, snoring, and breathing pauses decreased.</p><p><b>CONCLUSIONS: </b>A significant proportion of occult SDB in the general population would be missed if screening or case finding were based solely on increased body habitus or male sex. Breathing pauses and obesity may be particularly insensitive for identifying SDB in older people. A better understanding of predictive factors for SDB, particularly in older adults, is needed.</p> |
| DOI | 10.1001/archinte.162.8.893 |
| Alternate Journal | Arch Intern Med |
| PubMed ID | 11966340 |
| Grant List | U01HL53916 / HL / NHLBI NIH HHS / United States U01HL53931 / HL / NHLBI NIH HHS / United States U01HL53937 / HL / NHLBI NIH HHS / United States U01HL53938 / HL / NHLBI NIH HHS / United States U01HL53940 / HL / NHLBI NIH HHS / United States U01HL53941 / HL / NHLBI NIH HHS / United States U11HL5394 / HL / NHLBI NIH HHS / United States |