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Risk of dementia and death in the long-term follow-up of the Pittsburgh Cardiovascular Health Study-Cognition Study.
Tuesday,2015-11-03 11:14 America/Los_Angeles — zdrager
| Title | Risk of dementia and death in the long-term follow-up of the Pittsburgh Cardiovascular Health Study-Cognition Study. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Kuller, LH, Lopez, OL, Becker, JT, Chang, Y, Newman, AB |
| Journal | Alzheimers Dement |
| Volume | 12 |
| Issue | 2 |
| Pagination | 170-83 |
| Date Published | 2016 Feb |
| ISSN | 1552-5279 |
| Keywords | African Continental Ancestry Group, Aged, Aged, 80 and over, Apolipoprotein E4, Brain, Cardiovascular Diseases, Cognition, Dementia, European Continental Ancestry Group, Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Pennsylvania, Risk Factors, Walking |
| Abstract | <p><b>INTRODUCTION: </b>Increasing life expectancy has resulted in a larger population of older individuals at risk of dementia.</p><p><b>METHODS: </b>The Cardiovascular Health Study-Cognition Study followed 532 participants from 1998-99 (mean age 79) to 2013 (mean age 93) for death and dementia.</p><p><b>RESULTS: </b>Risk of death was determined by extent of coronary artery calcium, high-sensitivity cardiac troponin, brain natriuretic peptide, and white matter grade. Significant predictors of dementia were age, apolipoprotein-E4, vocabulary raw score, hippocampal volume, ventricular size, cognitive performance, and number of blocks walked. By 2013, 160 of 532 were alive, including 19 cognitively normal. Those with normal cognition had higher grade education, better cognition test scores, greater hippocampal volume, faster gait speed, and number of blocks walked as compared with survivors who were demented.</p><p><b>DISCUSSION: </b>Few survived free of dementia and disability. Prevention and delay of cognitive decline for this older population is an imperative.</p> |
| DOI | 10.1016/j.jalz.2015.08.165 |
| Alternate Journal | Alzheimers Dement |
| PubMed ID | 26519786 |
| PubMed Central ID | PMC4744537 |
| Grant List | HHSN268200800007C / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States N01 HC085082 / HC / NHLBI NIH HHS / United States N01 HC85079 / HC / NHLBI NIH HHS / United States N01HC15103 / HC / NHLBI NIH HHS / United States N01HC35129 / HC / NHLBI NIH HHS / United States N01HC55222 / HC / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01HC85080 / HC / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85081 / HC / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States N01HC85082 / HC / NHLBI NIH HHS / United States N01HC85083 / HC / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85086 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States P50 AG005133 / AG / NIA NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States U01HL080295 / HL / NHLBI NIH HHS / United States |