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Associations of Plasma Phospholipid SFAs with Total and Cause-Specific Mortality in Older Adults Differ According to SFA Chain Length.
Tuesday,2016-01-12 11:58 America/Los_Angeles — zdrager
| Title | Associations of Plasma Phospholipid SFAs with Total and Cause-Specific Mortality in Older Adults Differ According to SFA Chain Length. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Fretts, AM, Mozaffarian, D, Siscovick, DS, King, IB, McKnight, B, Psaty, BM, Rimm, EB, Sitlani, C, Sacks, FM, Song, X, Sotoodehnia, N, Spiegelman, D, Lemaitre, RN |
| Journal | J Nutr |
| Volume | 146 |
| Issue | 2 |
| Pagination | 298-305 |
| Date Published | 2016 Feb |
| ISSN | 1541-6100 |
| Keywords | Aged, Aged, 80 and over, Cause of Death, Diet, Dietary Fats, Eicosanoic Acids, Fatty Acids, Female, Humans, Male, Mortality, Palmitic Acid, Phospholipids, Prospective Studies, Risk Factors, Stearic Acids |
| Abstract | <p><b>BACKGROUND: </b>Not much is known about the relations of circulating saturated fatty acids (SFAs), which are influenced by both metabolic and dietary determinants, with total and cause-specific mortality.</p><p><b>OBJECTIVE: </b>We examined the associations of plasma phospholipid SFAs with total and cause-specific mortality among 3941 older adults from the Cardiovascular Health Study, a population-based prospective study of adults aged ≥65 y who were followed from 1992 through 2011.</p><p><b>METHODS: </b>The relations of total and cause-specific mortality with plasma phospholipid palmitic acid (16:0), stearic acid (18:0), arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) were assessed using Cox proportional hazards models.</p><p><b>RESULTS: </b>During 45,450 person-years of follow-up, 3134 deaths occurred. Higher concentrations of the plasma phospholipid SFAs 18:0, 22:0, and 24:0 were associated with a lower risk of total mortality [multivariable-adjusted HRs (95% CIs)] for the top compared with the bottom quintile: 0.85 (0.75, 0.95) for 18:0; 0.85 (0.75, 0.95) for 22:0; and 0.80 (0.71, 0.90) for 24:0. In contrast, plasma 16:0 concentrations in the highest quintile were associated with a higher risk of total mortality compared with concentrations in the lowest quintile [1.25 (1.11, 1.41)]. We also found no association of plasma phospholipid 20:0 with total mortality.</p><p><b>CONCLUSIONS: </b>These findings suggest that the associations of plasma phospholipid SFAs with the risk of death differ according to SFA chain length and support future studies to better characterize the determinants of circulating SFAs and to explore the mechanisms underlying these relations.</p> |
| DOI | 10.3945/jn.115.222117 |
| Alternate Journal | J. Nutr. |
| PubMed ID | 26701797 |
| PubMed Central ID | PMC4870839 |
| Grant List | 5KL2TR000421 / TR / NCATS NIH HHS / United States HHSN268200800007C / / PHS HHS / United States HHSN268201200036C / / PHS HHS / United States N01HC55222 / HC / NHLBI NIH HHS / United States N01HC85079 / HC / NHLBI NIH HHS / United States N01HC85080 / HC / NHLBI NIH HHS / United States N01HC85081 / HC / NHLBI NIH HHS / United States N01HC85082 / HC / NHLBI NIH HHS / United States N01HC85083 / HC / NHLBI NIH HHS / United States N01HC85086 / HC / NHLBI NIH HHS / United States R01-HL085710 / HL / NHLBI NIH HHS / United States R01AG023629 / AG / NIA NIH HHS / United States T32HL007902 / HL / NHLBI NIH HHS / United States U01HL080295 / HL / NHLBI NIH HHS / United States |