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FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals.

Wednesday,2016-01-13 12:31 America/Los_Angeles — zdrager
TitleFTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals.
Publication TypeJournal Article
Year of Publication2014
AuthorsQi, Q, Kilpeläinen, TO, Downer, MK, Tanaka, T, Smith, CE, Sluijs, I, Sonestedt, E, Chu, AY, Renstrom, F, Lin, X, Ängquist, LH, Huang, J, Liu, Z, Li, Y, Ali, MAsif, Xu, M, Ahluwalia, TSingh, Boer, JMA, Chen, P, Daimon, M, Eriksson, J, Perola, M, Friedlander, Y, Gao, Y-T, Heppe, DHM, Holloway, JW, Houston, DK, Kanoni, S, Kim, Y-M, Laaksonen, MA, Jääskeläinen, T, Lee, NR, Lehtimäki, T, Lemaitre, RN, Lu, W, Luben, RN, Manichaikul, A, Männistö, S, Marques-Vidal, P, Monda, KL, Ngwa, JS, Perusse, L, van Rooij, FJA, Xiang, Y-B, Wen, W, Wojczynski, MK, Zhu, J, Borecki, IB, Bouchard, C, Cai, Q, Cooper, C, Dedoussis, GV, Deloukas, P, Ferrucci, L, Forouhi, NG, Hansen, T, Christiansen, L, Hofman, A, Johansson, I, Jørgensen, T, Karasawa, S, Khaw, K-T, Kim, M-K, Kristiansson, K, Li, H, Lin, X, Liu, Y, Lohman, KK, Long, J, Mikkilä, V, Mozaffarian, D, North, K, Pedersen, O, Raitakari, O, Rissanen, H, Tuomilehto, J, van der Schouw, YT, Uitterlinden, AG, Zillikens, CM, Franco, OH, E Tai, S, Shu, XOu, Siscovick, DS, Toft, U, Verschuren, WMMonique, Vollenweider, P, Wareham, NJ, Witteman, JCM, Zheng, W, Ridker, PM, Kang, JH, Liang, L, Jensen, MK, Curhan, GC, Pasquale, LR, Hunter, DJ, Mohlke, KL, Uusitupa, M, Cupples, AL, Rankinen, T, Orho-Melander, M, Wang, T, Chasman, DI, Franks, PW, Sørensen, TIA, Hu, FB, Loos, RJF, Nettleton, JA, Qi, L
JournalHum Mol Genet
Volume23
Issue25
Pagination6961-72
Date Published2014 Dec 20
ISSN1460-2083
KeywordsAdult, African Americans, Aged, Alleles, Asian Continental Ancestry Group, Body Mass Index, Dietary Carbohydrates, Dietary Fats, Dietary Proteins, Energy Intake, European Continental Ancestry Group, Female, Gene Frequency, Humans, Male, Middle Aged, Obesity, Polymorphism, Single Nucleotide, Proteins
Abstract<p>FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is complex and results from previous often small-scale studies in humans are highly inconsistent. We performed large-scale analyses based on data from 177,330 adults (154 439 Whites, 5776 African Americans and 17 115 Asians) from 40 studies to examine: (i) the association between the FTO-rs9939609 variant (or a proxy single-nucleotide polymorphism) and total energy and macronutrient intake and (ii) the interaction between the FTO variant and dietary intake on BMI. The minor allele (A-allele) of the FTO-rs9939609 variant was associated with higher BMI in Whites (effect per allele = 0.34 [0.31, 0.37] kg/m(2), P = 1.9 × 10(-105)), and all participants (0.30 [0.30, 0.35] kg/m(2), P = 3.6 × 10(-107)). The BMI-increasing allele of the FTO variant showed a significant association with higher dietary protein intake (effect per allele = 0.08 [0.06, 0.10] %, P = 2.4 × 10(-16)), and relative weak associations with lower total energy intake (-6.4 [-10.1, -2.6] kcal/day, P = 0.001) and lower dietary carbohydrate intake (-0.07 [-0.11, -0.02] %, P = 0.004). The associations with protein (P = 7.5 × 10(-9)) and total energy (P = 0.002) were attenuated but remained significant after adjustment for BMI. We did not find significant interactions between the FTO variant and dietary intake of total energy, protein, carbohydrate or fat on BMI. Our findings suggest a positive association between the BMI-increasing allele of FTO variant and higher dietary protein intake and offer insight into potential link between FTO, dietary protein intake and adiposity.</p>
DOI10.1093/hmg/ddu411
Alternate JournalHum. Mol. Genet.
PubMed ID25104851
PubMed Central IDPMC4271061
Grant List14136 / / Cancer Research UK / United Kingdom
17702 / / Arthritis Research UK / United Kingdom
263 MD 821336 / MD / NIMHD NIH HHS / United States
263 MD 9164 / MD / NIMHD NIH HHS / United States
5P30DK46200 / DK / NIDDK NIH HHS / United States
5R01 DK06833603 / DK / NIDDK NIH HHS / United States
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ES10126 / ES / NIEHS NIH HHS / United States
EY015473 / EY / NEI NIH HHS / United States
G0701863 / / Medical Research Council / United Kingdom
G1000143 / / Medical Research Council / United Kingdom
GR-15187 / / Canadian Institutes of Health Research / Canada
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MC_U106179471 / / Medical Research Council / United Kingdom
MC_UP_A100_1003 / / Medical Research Council / United Kingdom
MC_UP_A620_1014 / / Medical Research Council / United Kingdom
MC_UU_12011/1 / / Medical Research Council / United Kingdom
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