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Serum potassium level and dietary potassium intake as risk factors for stroke.
Tuesday,2012-11-06 12:05 America/Los_Angeles — eenright
| Title | Serum potassium level and dietary potassium intake as risk factors for stroke. |
| Publication Type | Journal Article |
| Year of Publication | 2002 |
| Authors | Green, DM, Ropper, AH, Kronmal, RA, Psaty, BM, Burke, GL |
| Corporate/Institutional Authors | Cardiovascular Health Study, |
| Journal | Neurology |
| Volume | 59 |
| Issue | 3 |
| Pagination | 314-20 |
| Date Published | 2002 Aug 13 |
| ISSN | 0028-3878 |
| Keywords | Aged, Cohort Studies, Confidence Intervals, Diuretics, Humans, Linear Models, Male, Potassium, Potassium, Dietary, Proportional Hazards Models, Prospective Studies, Risk Factors, Stroke |
| Abstract | <p><b>BACKGROUND: </b>Numerous studies have found that low potassium intake and low serum potassium are associated with increased stroke mortality, but data regarding stroke incidence have been limited. Serum potassium levels, dietary potassium intake, and diuretic use in relation to risk for stroke in a prospectively studied cohort were investigated.</p><p><b>METHODS: </b>The study comprised 5,600 men and women older than 65 years who were free of stroke at enrollment. Baseline data included serum potassium level, dietary potassium intake, and diuretic use. Participants were followed for 4 to 8 years, and the incidence and types of strokes were recorded. Low serum potassium was defined as less than 4.1 mEq/L, and low potassium intake as less than 2.4 g/d.</p><p><b>RESULTS: </b>Among diuretic users, there was an increased risk for stroke associated with lower serum potassium (relative risk [RR]: 2.5, p < 0.0001). Among individuals not taking diuretics, there was an increased risk for stroke associated with low dietary potassium intake (RR: 1.5, p < 0.005). The small number of diuretic users with lower serum potassium and atrial fibrillation had a 10-fold greater risk for stroke compared with those with higher serum potassium and normal sinus rhythm.</p><p><b>CONCLUSIONS: </b>A lower serum potassium level in diuretic users, and low potassium intake in those not taking diuretics were associated with increased stroke incidence among older individuals. Lower serum potassium was associated with a particularly high risk for stroke in the small number of diuretic users with atrial fibrillation. Further study is required to determine if modification of these factors would prevent strokes.</p> |
| DOI | 10.1212/wnl.59.3.314 |
| Alternate Journal | Neurology |
| PubMed ID | 12177362 |
| Grant List | N01 HC 85079 / HC / NHLBI NIH HHS / United States N01 HC 85080 / HC / NHLBI NIH HHS / United States N01 HC 85081 / HC / NHLBI NIH HHS / United States N01 HC 85082 / HC / NHLBI NIH HHS / United States N01 HC 85083 / HC / NHLBI NIH HHS / United States N01 HC 85084 / HC / NHLBI NIH HHS / United States N01 HC 85085 / HC / NHLBI NIH HHS / United States N01 HC 85086 / HC / NHLBI NIH HHS / United States |