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Vitamin D and the risk of dementia and Alzheimer disease.
Wednesday,2016-04-13 11:23 America/Los_Angeles — zdrager
| Title | Vitamin D and the risk of dementia and Alzheimer disease. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Littlejohns, TJ, Henley, WE, Lang, IA, Annweiler, C, Beauchet, O, Chaves, PHM, Fried, L, Kestenbaum, BR, Kuller, LH, Langa, KM, Lopez, OL, Kos, K, Soni, M, Llewellyn, DJ |
| Journal | Neurology |
| Volume | 83 |
| Issue | 10 |
| Pagination | 920-8 |
| Date Published | 2014 Sep 2 |
| ISSN | 1526-632X |
| Keywords | Aged, Alzheimer Disease, Dementia, Female, Follow-Up Studies, Humans, Incidence, Male, Proportional Hazards Models, Risk Factors, United States, Vitamin D, Vitamin D Deficiency |
| Abstract | <p><b>OBJECTIVE: </b>To determine whether low vitamin D concentrations are associated with an increased risk of incident all-cause dementia and Alzheimer disease.</p><p><b>METHODS: </b>One thousand six hundred fifty-eight elderly ambulatory adults free from dementia, cardiovascular disease, and stroke who participated in the US population-based Cardiovascular Health Study between 1992-1993 and 1999 were included. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were determined by liquid chromatography-tandem mass spectrometry from blood samples collected in 1992-1993. Incident all-cause dementia and Alzheimer disease status were assessed during follow-up using National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association criteria.</p><p><b>RESULTS: </b>During a mean follow-up of 5.6 years, 171 participants developed all-cause dementia, including 102 cases of Alzheimer disease. Using Cox proportional hazards models, the multivariate adjusted hazard ratios (95% confidence interval [CI]) for incident all-cause dementia in participants who were severely 25(OH)D deficient (<25 nmol/L) and deficient (≥25 to <50 nmol/L) were 2.25 (95% CI: 1.23-4.13) and 1.53 (95% CI: 1.06-2.21) compared to participants with sufficient concentrations (≥50 nmol/L). The multivariate adjusted hazard ratios for incident Alzheimer disease in participants who were severely 25(OH)D deficient and deficient compared to participants with sufficient concentrations were 2.22 (95% CI: 1.02-4.83) and 1.69 (95% CI: 1.06-2.69). In multivariate adjusted penalized smoothing spline plots, the risk of all-cause dementia and Alzheimer disease markedly increased below a threshold of 50 nmol/L.</p><p><b>CONCLUSION: </b>Our results confirm that vitamin D deficiency is associated with a substantially increased risk of all-cause dementia and Alzheimer disease. This adds to the ongoing debate about the role of vitamin D in nonskeletal conditions.</p> |
| DOI | 10.1212/WNL.0000000000000755 |
| Alternate Journal | Neurology |
| PubMed ID | 25098535 |
| PubMed Central ID | PMC4153851 |
| Grant List | AG023629 / AG / NIA NIH HHS / United States AG15928 / AG / NIA NIH HHS / United States AG20098 / AG / NIA NIH HHS / United States HL084443 / HL / NHLBI NIH HHS / United States KMRF-2013-02-02 / / Department of Health / United Kingdom P30 DK035816 / DK / NIDDK NIH HHS / United States |