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Relationship between coronary artery calcification and other measures of subclinical cardiovascular disease in older adults.

TitleRelationship between coronary artery calcification and other measures of subclinical cardiovascular disease in older adults.
Publication TypeJournal Article
Year of Publication2002
AuthorsNewman, AB, Naydeck, BL, Sutton-Tyrrell, K, Edmundowicz, D, O'Leary, D, Kronmal, R, Burke, GL, Kuller, LH
JournalArterioscler Thromb Vasc Biol
Volume22
Issue10
Pagination1674-9
Date Published2002 Oct 01
ISSN1524-4636
KeywordsAged, Aged, 80 and over, Calcinosis, Cardiovascular Diseases, Carotid Stenosis, Cohort Studies, Coronary Artery Disease, Demography, Female, Humans, Male, Prevalence, Risk Factors, Sensitivity and Specificity, Sex Factors, Tomography, X-Ray Computed, Tunica Intima, Tunica Media
Abstract<p><b>BACKGROUND: </b>In the Cardiovascular Health Study, subclinical cardiovascular disease (CVD) predicted CVD events in older adults. The extent to which this measure or its components reflect calcified coronary disease is unknown.</p><p><b>METHODS AND RESULTS: </b>Coronary artery calcium (CAC) was assessed with electron beam tomography in 414 participants without clinical CVD and examined using cut points (CAC> or =400 and CAC> or =800) and the log(CAC); 274 had subclinical CVD by ankle-arm index, ECG, or carotid ultrasound. Cut points for subclinical disease as previously defined in the Cardiovascular Health Study were examined as well as continuous measures to produce receiver operating characteristic curve curves. A low ankle-arm index was highly specific for a high CAC score. The internal carotid artery intima-media thickness was most strongly correlated with CAC (r=0.30) and was significantly related to both CAC cut points and to the log(CAC) score independently of all other measures.</p><p><b>CONCLUSIONS: </b>In these community-dwelling older adults without clinical CVD, internal carotid artery intima-media thickness was most closely related to CAC. However, 17.5% of those with a CAC> or =400 would be missed in the ascertainment of subclinical atherosclerosis using the previously published composite of subclinical atherosclerosis. Prospective follow-up will determine whether the CAC score improves prediction of CVD events over other noninvasive measures.</p>
DOI10.1161/01.atv.0000033540.89672.24
Alternate JournalArterioscler Thromb Vasc Biol
PubMed ID12377748
Grant ListN01-HC-85079- / HC / NHLBI NIH HHS / United States
N01-HC-85080 / HC / NHLBI NIH HHS / United States
N01-HC-85081 / HC / NHLBI NIH HHS / United States
N01-HC-85082 / HC / NHLBI NIH HHS / United States
N01-HC-85083 / HC / NHLBI NIH HHS / United States
N01-HC-85084 / HC / NHLBI NIH HHS / United States
N01-HC-85085 / HC / NHLBI NIH HHS / United States
N01-HC-85086 / HC / NHLBI NIH HHS / United States
R01-HL-64587 / HL / NHLBI NIH HHS / United States