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Trajectories of function and biomarkers with age: the CHS All Stars Study.
Wednesday,2016-08-17 16:35 America/Los_Angeles — zdrager
| Title | Trajectories of function and biomarkers with age: the CHS All Stars Study. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Newman, AB, Sanders, JL, Kizer, JR, Boudreau, RM, Odden, MC, Hazzouri, AZeki Al, Arnold, AM |
| Journal | Int J Epidemiol |
| Date Published | 2016 Jun 6 |
| ISSN | 1464-3685 |
| Abstract | <p><b>BACKGROUND: </b>Multimorbidity is a major driver of physical and cognitive impairment, but rates of decline are also related to ageing. We sought to determine trajectories of decline in a large cohort by disease status, and examined their correspondence with biomarkers of ageing processes including growth hormone, sex steroid, inflammation, visceral adiposity and kidney function pathways.</p><p><b>METHODS: </b>We have followed the 5888 participants in the Cardiovascular Health Study (CHS) for healthy ageing and longevity since 1989-90. Gait speed, grip strength, modified mini-mental status examination (3MSE) and the digit symbol substitution test (DSST) were assessed annually to 1998-99 and again in 2005-06. Insulin-like growth hormone (IGF-1), dehydroepiandrosterone sulphate (DHEAS), interleukin-6 (IL-6), adiponectin and cystatin-C were assessed 3-5 times from stored samples. Health status was updated annually and dichotomized as healthy vs not healthy. Trajectories for each function measure and biomarker were estimated using generalized estimating equations as a function of age and health status using standardized values.</p><p><b>RESULTS: </b>Trajectories of functional decline showed strong age acceleration late in life in healthy older men and women as well as in chronically ill older adults. Adiponectin, IL-6 and cystatin-C tracked with functional decline in all domains; cystatin-C was consistently associated with functional declines independent of other biomarkers. DHEAS was independently associated with grip strength and IL-6 with grip strength and gait speed trajectories.</p><p><b>CONCLUSIONS: </b>Functional decline in late life appears to mark a fundamental ageing process in that it occurred and was accelerated in late life regardless of health status. Cystatin C was most consistently associated with these functional declines.</p> |
| DOI | 10.1093/ije/dyw092 |
| Alternate Journal | Int J Epidemiol |
| PubMed ID | 27272182 |