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Insulinlike growth factor binding protein-1 and ghrelin predict health outcomes among older adults: CHS cohort.
Friday,2016-12-16 21:31 America/Los_Angeles — ecterry
| Title | Insulinlike growth factor binding protein-1 and ghrelin predict health outcomes among older adults: CHS cohort. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Kaplan, RC, Strizich, G, Aneke-Nash, C, Dominguez-Islas, C, Bůzková, P, Strickler, H, Rohan, T, Pollak, M, Kuller, L, Kizer, JR, Cappola, A, Li, CI, Psaty, BM, Newman, A |
| Journal | J Clin Endocrinol Metab |
| Pagination | jc20162779 |
| Date Published | 2016 Nov 07 |
| ISSN | 1945-7197 |
| Abstract | <p><b>CONTEXT: </b>Multiple diseases may explain the association of the growth hormone / insulinlike growth factor-I (GH/IGF-I) axis with longevity.</p><p><b>OBJECTIVE: </b>To relate circulating GH/IGF-I system protein levels with major health events.</p><p><b>DESIGN: </b>Cohort study Setting: Four US communities Participants: Adults (n=2268) 65 years and older free of diabetes and cardiovascular disease.</p><p><b>MEASUREMENTS: </b>We assessed insulinlike growth factor binding protein-1 (IGFBP-1) and ghrelin in fasting and 2-hour oral glucose tolerance test (OGTT) blood samples, as well as fasting IGF-I and IGFBP-3. Hazard ratios for mortality and a composite outcome for first incident myocardial infarction, stroke, heart failure, hip fracture, or death were adjusted for sociodemographic, behavioral, and physiologic covariates.</p><p><b>RESULTS: </b>During 13,930 person-years of follow-up, 48.1% individuals sustained one or more components of the composite outcome and 31.8% died. Versus the lowest quartiles, the highest quartiles of fasting and 2-h ghrelin were associated with a 27% higher (95% CI: 6%, 53%) and 39% higher (95% CI: 14%, 71%) risks of the composite outcome, respectively. The highest quartile of 2-h IGFBP-1 was associated with 35% higher (95% CI: 1%, 52%) risk of the composite endpoint. Similarly, higher mortality was significantly associated with higher fasting and 2-h ghrelin level, and with 2-h IGFBP-1 level. When examined together, 2-h post-OGTT levels of IGFBP-1 and ghrelin tended to predict outcomes better than fasting levels.</p><p><b>CONCLUSIONS: </b>Circulating IGFBP-1 and ghrelin measured during an OGTT predict major health events and death in older adults, which may explain the influence of the GH-IGF-axis on lifespan and health.</p> |
| DOI | 10.1210/jc.2016-2779 |
| Alternate Journal | J. Clin. Endocrinol. Metab. |
| PubMed ID | 27820656 |
| Grant List | T32 GM007288 / GM / NIGMS NIH HHS / United States |
ePub date:
16/11