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Prospective study of alcohol consumption and risk of dementia in older adults.
Tuesday,2012-11-06 12:06 America/Los_Angeles — eenright
| Title | Prospective study of alcohol consumption and risk of dementia in older adults. |
| Publication Type | Journal Article |
| Year of Publication | 2003 |
| Authors | Mukamal, KJ, Kuller, LH, Fitzpatrick, AL, Longstreth, WT, Mittleman, MA, Siscovick, DS |
| Journal | JAMA |
| Volume | 289 |
| Issue | 11 |
| Pagination | 1405-13 |
| Date Published | 2003 Mar 19 |
| ISSN | 0098-7484 |
| Keywords | Aged, Alcohol Drinking, Apolipoprotein E4, Apolipoproteins E, Brain, Case-Control Studies, Dementia, Female, Humans, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Prospective Studies, Risk |
| Abstract | <p><b>CONTEXT: </b>Alcohol consumption has been associated with complex changes in cerebral vasculature and structure in older adults. How alcohol consumption affects the incidence of dementia is less clear.</p><p><b>OBJECTIVE: </b>To determine the prospective relationship of alcohol consumption and risk of dementia among older adults.</p><p><b>DESIGN, SETTING, AND PARTICIPANTS: </b>Nested case-control study of 373 cases with incident dementia and 373 controls who were among 5888 adults aged 65 years and older who participated in the Cardiovascular Health Study, a prospective, population-based cohort study in 4 US communities. The controls were frequency-matched on age, death before 1999, and their attendance of a 1998-1999 clinic. Participants in this study underwent magnetic resonance imaging (MRI) of the brain and cognitive testing between 1992 and 1994 and were followed up until 1999.</p><p><b>MAIN OUTCOME MEASURES: </b>Odds of incident dementia, ascertained by detailed neurological and neuropsychological examinations according to average alcohol consumption, assessed by self-reported intake of beer, wine, and liquor at 2 visits prior to the date of the MRI.</p><p><b>RESULTS: </b>Compared with abstention, the adjusted odds for dementia among those whose weekly alcohol consumption was less than 1 drink were 0.65 (95% confidence interval [CI], 0.41-1.02); 1 to 6 drinks, 0.46 (95% CI, 0.27-0.77); 7 to 13 drinks, 0.69 (95% CI, 0.37-1.31); and 14 or more drinks, 1.22 (95% CI, 0.60-2.49; P for quadratic term =.001). A trend toward greater odds of dementia associated with heavier alcohol consumption was most apparent among men and participants with an apolipoprotein E epsilon4 allele. We found generally similar relationships of alcohol use with Alzheimer disease and vascular dementia.</p><p><b>CONCLUSIONS: </b>Compared with abstention, consumption of 1 to 6 drinks weekly is associated with a lower risk of incident dementia among older adults.</p> |
| DOI | 10.1001/jama.289.11.1405 |
| Alternate Journal | JAMA |
| PubMed ID | 12636463 |
| Grant List | K23AA00299 / AA / NIAAA NIH HHS / United States N01HC15103 / HC / NHLBI NIH HHS / United States N01HC85079 / HC / NHLBI NIH HHS / United States N01HC85080 / HC / NHLBI NIH HHS / United States N01HC85081 / HC / NHLBI NIH HHS / United States N01HC85082 / HC / NHLBI NIH HHS / United States N01HC85083 / HC / NHLBI NIH HHS / United States N01HC85084 / HC / NHLBI NIH HHS / United States N01HC85085 / HC / NHLBI NIH HHS / United States N01HC85086 / HC / NHLBI NIH HHS / United States R01AG015928 / AG / NIA NIH HHS / United States |