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Beta2-adrenergic receptor polymorphisms and risk of incident cardiovascular events in the elderly.
Tuesday,2012-11-06 12:06 America/Los_Angeles — eenright
| Title | Beta2-adrenergic receptor polymorphisms and risk of incident cardiovascular events in the elderly. |
| Publication Type | Journal Article |
| Year of Publication | 2003 |
| Authors | Heckbert, SR, Hindorff, LA, Edwards, KL, Psaty, BM, Lumley, T, Siscovick, DS, Tang, Z, J Durda, P, Kronmal, RA, Tracy, RP |
| Journal | Circulation |
| Volume | 107 |
| Issue | 15 |
| Pagination | 2021-4 |
| Date Published | 2003 Apr 22 |
| ISSN | 1524-4539 |
| Keywords | African Continental Ancestry Group, Aged, Alleles, Brain Ischemia, Cardiovascular Diseases, Cohort Studies, Comorbidity, Coronary Disease, European Continental Ancestry Group, Follow-Up Studies, Gene Frequency, Humans, Incidence, Linkage Disequilibrium, Polymorphism, Genetic, Receptors, Adrenergic, beta-2, Risk Assessment, Stroke, United States |
| Abstract | <p><b>BACKGROUND: </b>Genetic polymorphisms at codons 16 and 27 of the beta2-adrenergic receptor have been associated with altered response to sympathetic stimulation. We examined these polymorphisms in relation to cardiovascular event risk in the Cardiovascular Health Study.</p><p><b>METHODS AND RESULTS: </b>A total of 808 black and 4441 white participants (mean age, 73 years) were genotyped for the Arg16Gly and Gln27Glu polymorphisms of the beta2-adrenergic receptor. There were 702 incident coronary events, 438 ischemic strokes, and 1136 combined cardiovascular events during 7 to 10 years of follow-up. Allele frequencies differed by race but not by age or hypertension status. Glu27 carriers had a lower risk of coronary events than Gln27 homozygotes (hazard ratio, 0.82; 95% CI, 0.70 to 0.95), and there was a suggestion of decreased risk among Gly16 carriers compared with Arg16 homozygotes (hazard ratio, 0.88; 95% CI, 0.72 to 1.07). There was no association of beta2-adrenergic receptor genotype with ischemic stroke or combined cardiovascular events.</p><p><b>CONCLUSIONS: </b>The Glu27 allele of the beta2-adrenergic receptor was associated with a lower risk of incident coronary events in this elderly population.</p> |
| DOI | 10.1161/01.CIR.0000065231.07729.92 |
| Alternate Journal | Circulation |
| PubMed ID | 12682000 |
| Grant List | R01 CA149051 / CA / NCI NIH HHS / United States N01-HC-85085 / HC / NHLBI NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States AG09556 / AG / NIA NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01-HC-85082 / HC / NHLBI NIH HHS / United States N01-HC-35129 / HC / NHLBI NIH HHS / United States AG15366 / AG / NIA NIH HHS / United States N01-HC-85083 / HC / NHLBI NIH HHS / United States N01-HC-85080 / HC / NHLBI NIH HHS / United States N01 HC-15103 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85084 / HC / NHLBI NIH HHS / United States |