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Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study.
Thursday,2017-04-27 16:55 America/Los_Angeles — ecterry
| Title | Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Ahiawodzi, PD, Kerber, RA, Taylor, KC, Groves, FD, O'Brien, E, Ix, JH, Kizer, JR, Djoussé, L, Tracy, RP, Newman, AB, Siscovick, DS, Robbins, J, Mukamal, K |
| Journal | Biomarkers |
| Volume | 22 |
| Issue | 3-4 |
| Pagination | 361-366 |
| Date Published | 2017 May - Jun |
| ISSN | 1366-5804 |
| Abstract | <p><b>CONTEXT: </b>Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease.</p><p><b>OBJECTIVE: </b>The objective of this study is to investigate the association between sleep-disordered breathing (SDB) - a source of oxidative stress - and CML.</p><p><b>MATERIALS AND METHODS: </b>About 1002 participants in the Cardiovascular Health Study (CHS) were studied.</p><p><b>RESULTS: </b>Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03-2.58, p = 0.04). The association was not significant among men.</p><p><b>DISCUSSION: </b>SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study.</p><p><b>CONCLUSION: </b>Accumulation of CML may be an adverse health consequence of SDB.</p> |
| DOI | 10.1080/1354750X.2016.1276966 |
| Alternate Journal | Biomarkers |
| PubMed ID | 28055285 |
ePub date:
17/05