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Association of Plasma SDF-1 with Bone Mineral Density, Body Composition, and Hip Fractures in Older Adults: The Cardiovascular Health Study.
Monday,2017-05-01 16:09 America/Los_Angeles — ecterry
| Title | Association of Plasma SDF-1 with Bone Mineral Density, Body Composition, and Hip Fractures in Older Adults: The Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Carbone, LD, Bůzková, P, Fink, HA, Robbins, JA, Bethel, M, Hamrick, MW, Hill, WD |
| Journal | Calcif Tissue Int |
| Volume | 100 |
| Issue | 6 |
| Pagination | 599-608 |
| Date Published | 2017 Jun |
| ISSN | 1432-0827 |
| Abstract | <p>Aging is associated with an increase in circulating inflammatory factors. One, the cytokine stromal cell-derived factor 1 (SDF-1 or CXCL12), is critical to stem cell mobilization, migration, and homing as well as to bone marrow stem cell (BMSC), osteoblast, and osteoclast function. SDF-1 has pleiotropic roles in bone formation and BMSC differentiation into osteoblasts/osteocytes, and in osteoprogenitor cell survival. The objective of this study was to examine the association of plasma SDF-1 in participants in the cardiovascular health study (CHS) with bone mineral density (BMD), body composition, and incident hip fractures. In 1536 CHS participants, SDF-1 plasma levels were significantly associated with increasing age (p < 0.01) and male gender (p = 0.04), but not with race (p = 0.63). In multivariable-adjusted models, higher SDF-1 levels were associated with lower total hip BMD (p = 0.02). However, there was no significant association of SDF-1 with hip fractures (p = 0.53). In summary, circulating plasma levels of SDF-1 are associated with increasing age and independently associated with lower total hip BMD in both men and women. These findings suggest that SDF-1 levels are linked to bone homeostasis.</p> |
| DOI | 10.1007/s00223-017-0245-8 |
| Alternate Journal | Calcif. Tissue Int. |
| PubMed ID | 28246930 |
ePub date:
17/02