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Higher plasma transforming growth factor (TGF)-β is associated with kidney disease in older community dwelling adults.
Tuesday,2017-05-02 15:55 America/Los_Angeles — ecterry
| Title | Higher plasma transforming growth factor (TGF)-β is associated with kidney disease in older community dwelling adults. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Mehta, T, Bůzková, P, Kizer, JR, Djoussé, L, Chonchol, M, Mukamal, KJ, Shlipak, M, Ix, JH, Jalal, D |
| Journal | BMC Nephrol |
| Volume | 18 |
| Issue | 1 |
| Pagination | 98 |
| Date Published | 2017 Mar 21 |
| ISSN | 1471-2369 |
| Abstract | <p><b>BACKGROUND: </b>TGF-β is induced in the vasculature with aging suggesting that high plasma TGF-β levels may be a risk factor for chronic kidney disease (CKD) in older adults.</p><p><b>METHODS: </b>We conducted a cross-sectional analysis of the association between plasma TGF-β levels and CKD including data for 1722 older adults who had participated in the 1996/97 visit of the Cardiovascular Health Study (CHS). Prevalent CKD was defined as eGFR < 60 mL/min/1.73 m(2) or urinary albumin/creatinine ratio (ACR) ≥30 mg/g. We also evaluated whether baseline TGF-β levels predicted change in eGFR, cardiovascular (CV) events, or mortality in longitudinal analysis.</p><p><b>RESULTS: </b>Plasma TGF-β levels were significantly and independently associated with lower eGFR in cross-sectional analysis. Doubling of TGF-β was significantly associated with lower eGFR (β estimate after adjusting for CV risk factors = -1.18, 95% CI -2.03, -0.32). We observed no association with albuminuria. There was no association between baseline TGF-β and change in eGFR, but each doubling of TGF-β at baseline was associated with increased risk of a composite outcome of CV events and mortality, adjusted HR 1.10 (95% C.I. 1.02- 1.20, p = 0.006).</p><p><b>CONCLUSION: </b>In this large cohort of community-dwelling older individuals, high plasma TGF-β levels are modestly, but independently associated with lower eGFR but not with albuminuria in cross-sectional analysis. In addition, TGF-β levels are associated with increased risk of CV events and mortality. Further research is needed to determine the direction of association between plasma TGF-β and the risk of CKD and CKD-associated morbidities in older adults.</p> |
| DOI | 10.1186/s12882-017-0509-6 |
| Alternate Journal | BMC Nephrol |
| PubMed ID | 28327102 |
| PubMed Central ID | PMC5359982 |
| Grant List | R01 DK098234 / DK / NIDDK NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States R01 HL094555 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States R01 HL080295 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States R56 AG023629 / AG / NIA NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States |
ePub date:
17/03