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Association of DPP-4 activity with BMD, body composition, and incident hip fracture: the Cardiovascular Health Study.
Wednesday,2017-05-03 14:12 America/Los_Angeles — ecterry
| Title | Association of DPP-4 activity with BMD, body composition, and incident hip fracture: the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Carbone, LD, Bůžková, P, Fink, HA, Robbins, JA, Bethel, M, Isales, CM, Hill, WD |
| Journal | Osteoporos Int |
| Volume | 28 |
| Issue | 5 |
| Pagination | 1631-1640 |
| Date Published | 2017 May |
| ISSN | 1433-2965 |
| Abstract | <p>There was no association of plasma DPP-4 activity levels with bone mineral density (BMD), body composition, or incident hip fractures in a cohort of elderly community-dwelling adults.</p><p><b>INTRODUCTION: </b>Dipeptidyl peptidase IV (DPP-4) inactivates several key hormones including those that stimulate postprandial insulin secretion, and DPP-4 inhibitors (gliptins) are approved to treat diabetes. While DPP-4 is known to modulate osteogenesis, the relationship between DPP-4 activity and skeletal health is uncertain. The purpose of the present study was to examine possible associations between DPP-4 activity in elderly subjects enrolled in the Cardiovascular Health Study (CHS) and BMD, body composition measurements, and incident hip fractures.</p><p><b>METHODS: </b>All 1536 male and female CHS participants who had evaluable DXA scans and plasma for DPP-4 activity were included in the analyses. The association between (1) BMD of the total hip, femoral neck, lumbar spine, and total body; (2) body composition measurements (% lean, % fat, and total body mass); and (3) incident hip fractures and plasma levels of DPP-4 activity were determined.</p><p><b>RESULTS: </b>Mean plasma levels of DPP-4 activity were significantly higher in blacks (227 ± 78) compared with whites (216 ± 89) (p = 0.04). However, there was no significant association of DPP-4 activity with age or gender (p ≥ 0.14 for both). In multivariable adjusted models, there was no association of plasma DPP-4 activity with BMD overall (p ≥ 0.55 for all) or in gender stratified analyses (p ≥ 0.23). There was also no association of DPP-4 levels and incident hip fractures overall (p ≥ 0.24) or in gender stratified analyses (p ≥ 0.39).</p><p><b>CONCLUSION: </b>Plasma DPP-4 activity, within the endogenous physiological range, was significantly associated with race, but not with BMD, body composition, or incident hip fractures in elderly community-dwelling subjects.</p> |
| DOI | 10.1007/s00198-017-3916-4 |
| Alternate Journal | Osteoporos Int |
| PubMed ID | 28150034 |
ePub date:
17/05