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The distribution of coagulation factors VII and VIII and fibrinogen in adults over 65 years. Results from the Cardiovascular Health Study.
Tuesday,2012-11-06 12:06 America/Los_Angeles — eenright
| Title | The distribution of coagulation factors VII and VIII and fibrinogen in adults over 65 years. Results from the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 1992 |
| Authors | Tracy, RP, Bovill, EG, Fried, LP, Heiss, G, Lee, MH, Polak, JF, Psaty, BM, Savage, PJ |
| Journal | Ann Epidemiol |
| Volume | 2 |
| Issue | 4 |
| Pagination | 509-19 |
| Date Published | 1992 Jul |
| ISSN | 1047-2797 |
| Keywords | African Continental Ancestry Group, Age Factors, Aged, Cardiovascular Diseases, Cohort Studies, Factor VII, Factor VIII, Female, Fibrinogen, Humans, Male, Middle Aged, Risk Factors |
| Abstract | <p>The Cardiovascular Health Study (CHS) was designed to examine cardiovascular disease and its risk factors in older adults. We report here the distributions of the coagulation factors fibrinogen, factor VII, and factor VIII in a population-based cohort of men and women 65 years or older. In other studies of middle-aged individuals, these factors were shown to be associated with cardiovascular risk. In the CHS cohort, all three factors were elevated, compared to levels reported in middle-aged individuals, and fibrinogen and factor VIII values were higher in each successive age group; factor VII values, in contrast, declined slightly with age in the CHS cohort. Compared to white subjects, blacks had higher values for fibrinogen and factor VIII and lower values for factor VII. While women had markedly higher values for factor VII and factor VIII than men at all ages in the CHS, mean fibrinogen values were not different between men and women.</p> |
| DOI | 10.1016/1047-2797(92)90100-5 |
| Alternate Journal | Ann Epidemiol |
| PubMed ID | 1342301 |
| Grant List | N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States |