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Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1.
Tuesday,2012-11-06 12:06 America/Los_Angeles — eenright
| Title | Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1. |
| Publication Type | Journal Article |
| Year of Publication | 2003 |
| Authors | Lopez, OL, Jagust, WJ, DeKosky, ST, Becker, JT, Fitzpatrick, A, Dulberg, C, Breitner, J, Lyketsos, C, Jones, B, Kawas, C, Carlson, M, Kuller, LH |
| Journal | Arch Neurol |
| Volume | 60 |
| Issue | 10 |
| Pagination | 1385-9 |
| Date Published | 2003 Oct |
| ISSN | 0003-9942 |
| Keywords | Aged, Aged, 80 and over, Cardiovascular Diseases, Cognition Disorders, Cohort Studies, Dementia, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Memory Disorders, Neuropsychological Tests, Pennsylvania, Population, Psychiatric Status Rating Scales |
| Abstract | <p><b>OBJECTIVE: </b>To examine the prevalence of mild cognitive impairment (MCI) and its diagnostic classification in the Cardiovascular Health Study (CHS) Cognition Study.</p><p><b>DESIGN: </b>The CHS Cognition Study is an ancillary study of the CHS that was conducted to determine the presence of MCI and dementia in the CHS cohort.</p><p><b>SETTING: </b>Multicenter population study.</p><p><b>PATIENTS: </b>We examined 3608 participants in the CHS who had undergone detailed neurological, neuropsychological, neuroradiological, and psychiatric testing to identify dementia and MCI.</p><p><b>MAIN OUTCOME MEASURES: </b>The prevalence of MCI was determined for the whole cohort, and specific subtypes of MCI were examined in detail only at the Pittsburgh, Pa, center (n = 927). Mild cognitive impairment was classified as either MCI amnestic-type or MCI multiple cognitive deficits-type.</p><p><b>RESULTS: </b>The overall prevalence of MCI was 19% (465 of 2470 participants); prevalence increased with age from 19% in participants younger than 75 years to 29% in those older than 85 years. The overall prevalence of MCI at the Pittsburgh center was 22% (130 of 599 participants); prevalence of the MCI amnesic-type was 6% and of the MCI multiple cognitive deficits-type was 16%.</p><p><b>CONCLUSIONS: </b>Twenty-two percent of the participants aged 75 years or older had MCI. Mild cognitive impairment is a heterogeneous syndrome, where the MCI amnestic-type is less frequent than the MCI multiple cognitive deficits-type. Most of the participants with MCI had comorbid conditions that may affect their cognitive functions.</p> |
| DOI | 10.1001/archneur.60.10.1385 |
| Alternate Journal | Arch Neurol |
| PubMed ID | 14568808 |
| Grant List | AG 20098 / AG / NIA NIH HHS / United States AG15928 / AG / NIA NIH HHS / United States K02-MH01077 / MH / NIMH NIH HHS / United States N01-HC-15103 / HC / NHLBI NIH HHS / United States N01-HC-35129 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85080 / HC / NHLBI NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States N01-HC-85082 / HC / NHLBI NIH HHS / United States N01-HC-85083 / HC / NHLBI NIH HHS / United States N01-HC-85084 / HC / NHLBI NIH HHS / United States N01-HC-85085 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States |