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Inflammation as a risk factor for atrial fibrillation.
Tuesday,2012-11-06 12:06 America/Los_Angeles — eenright
| Title | Inflammation as a risk factor for atrial fibrillation. |
| Publication Type | Journal Article |
| Year of Publication | 2003 |
| Authors | Aviles, RJ, Martin, DO, Apperson-Hansen, C, Houghtaling, PL, Rautaharju, P, Kronmal, RA, Tracy, RP, Van Wagoner, DR, Psaty, BM, Lauer, MS, Chung, MK |
| Journal | Circulation |
| Volume | 108 |
| Issue | 24 |
| Pagination | 3006-10 |
| Date Published | 2003 Dec 16 |
| ISSN | 1524-4539 |
| Keywords | Aged, Atrial Fibrillation, C-Reactive Protein, Cross-Sectional Studies, Female, Humans, Inflammation, Longitudinal Studies, Male, Risk Factors |
| Abstract | <p><b>BACKGROUND: </b>The presence of systemic inflammation determined by elevations in C-reactive protein (CRP) has been associated with persistence of atrial fibrillation (AF). The relationship between CRP and prediction of AF has not been studied in a large population-based cohort.</p><p><b>METHODS AND RESULTS: </b>CRP measurement and cardiovascular assessment were performed at baseline in 5806 subjects enrolled in the Cardiovascular Health Study. Patients were followed up for a mean of 6.9+/-1.6 (median 7.8) years. AF was identified by self-reported history and ECGs at baseline and by ECGs and hospital discharge diagnoses at follow-up. Univariate and multivariate analyses were used to assess CRP as a predictor of baseline and future development of AF. At baseline, 315 subjects (5%) had AF. Compared with subjects in the first CRP quartile (<0.97 mg/L), subjects in the fourth quartile (>3.41 mg/L) had more AF (7.4% versus 3.7%, adjusted OR 1.8, 95% CI 1.2 to 2.5; P=0.002). Of 5491 subjects without AF at baseline, 897 (16%) developed AF during follow-up. Baseline CRP predicted higher risk for developing future AF (fourth versus first quartile adjusted hazard ratio 1.31, 95% CI 1.08 to 1.58; P=0.005). When treated as a continuous variable, elevated CRP predicted increased risk for developing future AF (adjusted hazard ratio for 1-SD increase, 1.24; 95% CI 1.11 to 1.40; P<0.001).</p><p><b>CONCLUSIONS: </b>CRP is not only associated with the presence of AF but may also predict patients at increased risk for future development of AF.</p> |
| DOI | 10.1161/01.CIR.0000103131.70301.4F |
| Alternate Journal | Circulation |
| PubMed ID | 14623805 |
| Grant List | HL-65412 / HL / NHLBI NIH HHS / United States N01 HC-15103 / HC / NHLBI NIH HHS / United States N01-HC-35129 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85080 / HC / NHLBI NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States N01-HC-85082 / HC / NHLBI NIH HHS / United States N01-HC-85083 / HC / NHLBI NIH HHS / United States N01-HC-85084 / HC / NHLBI NIH HHS / United States N01-HC-85085 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States |