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Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent.

TitleGenome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent.
Publication TypeJournal Article
Year of Publication2017
AuthorsSmith, CE, Follis, JL, Dashti, HS, Tanaka, T, Graff, M, Fretts, AM, Kilpeläinen, TO, Wojczynski, MK, Richardson, K, Nalls, MA, Schulz, C-A, Liu, Y, Frazier-Wood, AC, van Eekelen, E, Wang, C, de Vries, PS, Mikkilä, V, Rohde, R, Psaty, BM, Hansen, T, Feitosa, MF, Lai, C-Q, Houston, DK, Ferruci, L, Ericson, U, Wang, Z, de Mutsert, R, Oddy, WH, de Jonge, EAL, Seppälä, I, Justice, AE, Lemaitre, RN, Sørensen, TIA, Province, MA, Parnell, LD, Garcia, ME, Bandinelli, S, Orho-Melander, M, Rich, SS, Rosendaal, FR, Pennell, CE, de Jong, JCKiefte-, Kähönen, M, Young, KL, Pedersen, O, Aslibekyan, S, Rotter, JI, Mook-Kanamori, DO, Zillikens, CM, Raitakari, OT, North, KE, Overvad, K, Arnett, DK, Hofman, A, Lehtimäki, T, Tjønneland, A, Uitterlinden, AG, Rivadeneira, F, Franco, OH, J German, B, Siscovick, DS, Cupples, AL, Ordovas, JM
JournalMol Nutr Food Res
Date Published2017 Sep 21
ISSN1613-4133
Abstract<p><b>SCOPE: </b>Body weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption.</p><p><b>METHODS AND RESULTS: </b>A genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta-analyzed. Twenty-six genetic variants reached the selected significance threshold (p-interaction <10-7) , and six independent variants (LINC01512-rs7751666, PALM2/AKAP2-rs914359, ACTA2-rs1388, PPP1R12A-rs7961195, LINC00333-rs9635058, AC098847.1-rs1791355) were evaluated meta-analytically for replication of interaction in up to 17 675 individuals. Variant rs9635058 (128 kb 3' of LINC00333) was replicated (p-interaction = 0.004). In the discovery cohorts, rs9635058 interacted with dairy (p-interaction = 7.36 × 10-8) such that each serving of low-fat dairy was associated with 0.225 kg m-2 lower BMI per each additional copy of the effect allele (A). A second genetic variant (ACTA2-rs1388) approached interaction replication significance for low-fat dairy exposure.</p><p><b>CONCLUSION: </b>Body weight responses to dairy intake may be modified by genotype, in that greater dairy intake may protect a genetic subgroup from higher body weight.</p>
DOI10.1002/mnfr.201700347
Alternate JournalMol Nutr Food Res
PubMed ID28941034
Grant ListK08 HL112845 / HL / NHLBI NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
ePub date: 
17/09