You are here

Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study.

TitleGenetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study.
Publication TypeJournal Article
Year of Publication2017
AuthorsSobrin, L, Chong, YHe, Fan, Q, Gan, A, Stanwyck, LK, Kaidonis, G, Craig, JE, Kim, J, Liao, W-L, Huang, Y-C, Lee, W-J, Hung, Y-J, Guo, X, Hai, Y, Ipp, E, Pollack, S, Hancock, H, Price, A, Penman, A, Mitchell, P, Liew, G, Smith, AV, Gudnason, V, Tan, G, Klein, BEK, Kuo, J, Li, X, Christiansen, MW, Psaty, BM, Sandow, K, Jensen, RA, Klein, R, Cotch, MFrances, Wang, JJin, Jia, Y, Chen, CJ, Chen, Y-DI, Rotter, JI, Tsai, F-J, Hanis, CL, Burdon, KP, Wong, TYin, Cheng, C-Y
Corporate/Institutional AuthorsAsian Genetic Epidemiology Network Consortium
JournalDiabetes
Volume66
Issue12
Pagination3130-3141
Date Published2017 12
ISSN1939-327X
KeywordsAged, Diabetic Retinopathy, Female, Genome-Wide Association Study, Humans, Lipids, Male, Mendelian Randomization Analysis, Middle Aged, Polymorphism, Single Nucleotide, Risk
Abstract<p>Results from observational studies examining dyslipidemia as a risk factor for diabetic retinopathy (DR) have been inconsistent. We evaluated the causal relationship between plasma lipids and DR using a Mendelian randomization approach. We pooled genome-wide association studies summary statistics from 18 studies for two DR phenotypes: any DR (N = 2,969 case and 4,096 control subjects) and severe DR (N = 1,277 case and 3,980 control subjects). Previously identified lipid-associated single nucleotide polymorphisms served as instrumental variables. Meta-analysis to combine the Mendelian randomization estimates from different cohorts was conducted. There was no statistically significant change in odds ratios of having any DR or severe DR for any of the lipid fractions in the primary analysis that used single nucleotide polymorphisms that did not have a pleiotropic effect on another lipid fraction. Similarly, there was no significant association in the Caucasian and Chinese subgroup analyses. This study did not show evidence of a causal role of the four lipid fractions on DR. However, the study had limited power to detect odds ratios less than 1.23 per SD in genetically induced increase in plasma lipid levels, thus we cannot exclude that causal relationships with more modest effect sizes exist.</p>
DOI10.2337/db17-0398
Alternate JournalDiabetes
PubMed ID28951389
PubMed Central IDPMC5697951
Grant ListHHSN268201500003C / HL / NHLBI NIH HHS / United States
N01HC95160 / HL / NHLBI NIH HHS / United States
N01HC95163 / HL / NHLBI NIH HHS / United States
U01 HL080295 / HL / NHLBI NIH HHS / United States
UL1 TR001079 / TR / NCATS NIH HHS / United States
U01 HL130114 / HL / NHLBI NIH HHS / United States
HHSN268200800007C / HL / NHLBI NIH HHS / United States
N01HC95169 / HL / NHLBI NIH HHS / United States
K12 EY016335 / EY / NEI NIH HHS / United States
HHSN268201300048C / HL / NHLBI NIH HHS / United States
N01HC95164 / HL / NHLBI NIH HHS / United States
N01HC55222 / HL / NHLBI NIH HHS / United States
N02HL64278 / HL / NHLBI NIH HHS / United States
N01HC95162 / HL / NHLBI NIH HHS / United States
N01HC85086 / HL / NHLBI NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
N01HC95168 / HL / NHLBI NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
HHSN268201300049C / HL / NHLBI NIH HHS / United States
HHSN268201200036C / HL / NHLBI NIH HHS / United States
N01HC95165 / HL / NHLBI NIH HHS / United States
N01HC95159 / HL / NHLBI NIH HHS / United States
N01HC95161 / HL / NHLBI NIH HHS / United States
HHSN268201300047C / HL / NHLBI NIH HHS / United States
HHSN268201300050C / HL / NHLBI NIH HHS / United States
ZIA AG007380 / AG / NIA NIH HHS / United States
N01HC85082 / HL / NHLBI NIH HHS / United States
N01HC75150 / HL / NHLBI NIH HHS / United States
N01HC95167 / HL / NHLBI NIH HHS / United States
N01HC85083 / HL / NHLBI NIH HHS / United States
UL1 TR000040 / TR / NCATS NIH HHS / United States
/ / Wellcome Trust / United Kingdom
HHSN268201300046C / HL / NHLBI NIH HHS / United States
N01HC85079 / HL / NHLBI NIH HHS / United States
N01HC95166 / HL / NHLBI NIH HHS / United States
R01 EY022302 / EY / NEI NIH HHS / United States
R01 AG023629 / AG / NIA NIH HHS / United States
UL1 TR001881 / TR / NCATS NIH HHS / United States
N01HC85080 / HL / NHLBI NIH HHS / United States
ZIA EY000401 / EY / NEI NIH HHS / United States
N01HC85081 / HL / NHLBI NIH HHS / United States
ePub date: 
17/12