You are here
Outdoor air pollution and mosaic loss of chromosome Y in older men from the Cardiovascular Health Study.
Tuesday,2018-05-01 17:15 America/Los_Angeles — ecterry
| Title | Outdoor air pollution and mosaic loss of chromosome Y in older men from the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Y Y Wong, J, Margolis, HG, Machiela, M, Zhou, W, Odden, MC, Psaty, BM, Robbins, J, Jones, RR, Rotter, JI, Chanock, SJ, Rothman, N, Lan, Q, Lee, JS |
| Journal | Environ Int |
| Volume | 116 |
| Pagination | 239-247 |
| Date Published | 2018 Apr 23 |
| ISSN | 1873-6750 |
| Abstract | <p><b>BACKGROUND: </b>Mosaic loss of chromosome Y (mLOY) can occur in a fraction of cells as men age, which is potentially linked to increased mortality risk. Smoking is related to mLOY; however, the contribution of air pollution is unclear.</p><p><b>OBJECTIVE: </b>We investigated whether exposure to outdoor air pollution, age, and smoking were associated with mLOY.</p><p><b>METHODS: </b>We analyzed baseline (1989-1993) blood samples from 933 men ≥65 years of age from the prospective Cardiovascular Health Study. Particulate matter ≤10 μm (PM), carbon monoxide, nitrogen dioxide, sulfur dioxide, and ozone data were obtained from the U.S. EPA Aerometric Information Retrieval System for the year prior to baseline. Inverse-distance weighted air monitor data were used to estimate each participants' monthly residential exposure. mLOY was detected with standard methods using signal intensity (median log-R ratio (mLRR)) of the male-specific chromosome Y regions from Illumina array data. Linear regression models were used to evaluate relations between mean exposure in the prior year, age, smoking and continuous mLRR.</p><p><b>RESULTS: </b>Increased PM was associated with mLOY, namely decreased mLRR (p-trend = 0.03). Compared with the lowest tertile (≤28.5 μg/m), the middle (28.5-31.0 μg/m; β = -0.0044, p = 0.09) and highest (≥31 μg/m; β = -0.0054, p = 0.04) tertiles had decreased mLRR, adjusted for age, clinic, race/cohort, smoking status and pack-years. Additionally, increasing age (β = -0.00035, p = 0.06) and smoking pack-years (β = -0.00011, p = 1.4E-3) were associated with decreased mLRR, adjusted for each other and race/cohort. No significant associations were found for other pollutants.</p><p><b>CONCLUSIONS: </b>PM may increase leukocyte mLOY, a marker of genomic instability. The sample size was modest and replication is warranted.</p> |
| DOI | 10.1016/j.envint.2018.04.030 |
| Alternate Journal | Environ Int |
| PubMed ID | 29698900 |
ePub date:
18/04