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Fasting and post-glucose load measures of insulin resistance and risk of incident atrial fibrillation: The Cardiovascular Health Study.
Tuesday,2018-05-01 17:17 America/Los_Angeles — ecterry
| Title | Fasting and post-glucose load measures of insulin resistance and risk of incident atrial fibrillation: The Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Garg, PK, Biggs, ML, Kaplan, R, Kizer, JR, Heckbert, SR, Mukamal, KJ |
| Journal | Nutr Metab Cardiovasc Dis |
| Date Published | 2018 Mar 02 |
| ISSN | 1590-3729 |
| Abstract | <p><b>BACKGROUND AND AIMS: </b>Existing literature in individuals without diabetes has not demonstrated a relationship between IR and incident AF; however, data are limited and only fasting glucose measures of IR were assessed. We evaluated the relationship of both fasting and post-glucose load IR measures with the development of atrial fibrillation in nondiabetic older adults.</p><p><b>METHODS AND RESULTS: </b>Among Cardiovascular Health Study participants, a population-based cohort of 5888 adults aged 65 years or older enrolled in two waves (1989-1990 and 1992-1993), those without prevalent AF or diabetes and with IR measures at baseline were followed for the development of AF, identified by follow-up visit electrocardiograms, hospital discharge diagnosis coding, or Medicare claims data, through 2014. Fasting IR was determined by the homeostatic model of insulin resistance (HOMA-IR) and post-glucose load IR was determined by the Gutt index. Cox proportional hazards models were used to determine the association of IR with risk of AF. Analyses included 3601 participants (41% men) with a mean age of 73 years. Over a median follow-up of 12.3 years, 1443 (40%) developed AF. After multivariate adjustment, neither HOMA-IR nor the Gutt index was associated with risk of developing AF [hazard ratios (95% confidence intervals): 0.96 (0.90, 1.03) for 1-SD increase in HOMA-IR and 1.03 (0.97, 1.10) for 1-SD decrease in the Gutt index].</p><p><b>CONCLUSIONS: </b>We found no evidence of an association between either fasting or post-glucose load IR measures and incident AF.</p> |
| DOI | 10.1016/j.numecd.2018.02.016 |
| Alternate Journal | Nutr Metab Cardiovasc Dis |
| PubMed ID | 29615289 |
ePub date:
18/03