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Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study.
Tuesday,2018-09-18 16:25 America/Los_Angeles — ecterry
| Title | Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Lindström, S, Germain, M, Crous-Bou, M, Smith, EN, Morange, P-E, Vlieg, Avan Hylcka, de Haan, HG, Chasman, D, Ridker, P, Brody, J, de Andrade, M, Heit, JA, Tang, W, DeVivo, I, Grodstein, F, Smith, NL, Tregouet, D, Kabrhel, C |
| Corporate/Institutional Authors | INVENT Consortium |
| Journal | Hum Genet |
| Volume | 136 |
| Issue | 7 |
| Pagination | 897-902 |
| Date Published | 2017 07 |
| ISSN | 1432-1203 |
| Keywords | Adult, Body Mass Index, Case-Control Studies, European Continental Ancestry Group, Female, Genome-Wide Association Study, Humans, Incidence, Logistic Models, Male, Mendelian Randomization Analysis, Obesity, Polymorphism, Single Nucleotide, Proportional Hazards Models, Venous Thromboembolism |
| Abstract | <p>Observational studies have shown an association between obesity and venous thromboembolism (VTE) but it is not known if observed associations are causal, due to reverse causation or confounding bias. We conducted a Mendelian Randomization study of body mass index (BMI) and VTE. We identified 95 single nucleotide polymorphisms (SNPs) that have been previously associated with BMI and assessed the association between genetically predicted high BMI and VTE leveraging data from a previously conducted GWAS within the INVENT consortium comprising a total of 7507 VTE cases and 52,632 controls of European ancestry. Five BMI SNPs were associated with VTE at P < 0.05, with the strongest association seen for the FTO SNP rs1558902 (OR 1.07, 95% CI 1.02-1.12, P = 0.005). In addition, we observed a significant association between genetically predicted BMI and VTE (OR = 1.59, 95% CI 1.30-1.93 per standard deviation increase in BMI, P = 5.8 × 10). Our study provides evidence for a causal relationship between high BMI and risk of VTE. Reducing obesity levels will likely result in lower incidence in VTE.</p> |
| DOI | 10.1007/s00439-017-1811-x |
| Alternate Journal | Hum. Genet. |
| PubMed ID | 28528403 |
| PubMed Central ID | PMC5531049 |
| Grant List | R01 HL095080 / HL / NHLBI NIH HHS / United States R01 HL083141 / HL / NHLBI NIH HHS / United States R01 HL068986 / HL / NHLBI NIH HHS / United States R01 HL043851 / HL / NHLBI NIH HHS / United States UM1 CA176726 / CA / NCI NIH HHS / United States R01 HL059367 / HL / NHLBI NIH HHS / United States R01 HL116854 / HL / NHLBI NIH HHS / United States R01 HL085251 / HL / NHLBI NIH HHS / United States R01 HL066216 / HL / NHLBI NIH HHS / United States U01 CA167552 / CA / NCI NIH HHS / United States R01 HL074745 / HL / NHLBI NIH HHS / United States U01 HL107442 / HL / NHLBI NIH HHS / United States R01 HL060739 / HB / NHLBI NIH HHS / United States UM1 CA186107 / CA / NCI NIH HHS / United States UM1 CA182913 / CA / NCI NIH HHS / United States R01 CA047988 / CA / NCI NIH HHS / United States R01 HL080467 / HL / NHLBI NIH HHS / United States R01 HL043201 / HL / NHLBI NIH HHS / United States UM1 CA167552 / CA / NCI NIH HHS / United States R01 HL060739 / HL / NHLBI NIH HHS / United States U01 HG004735 / HG / NHGRI NIH HHS / United States R01 HL073410 / HL / NHLBI NIH HHS / United States |
ePub date:
17/07