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Atrial fibrillation in an African-American cohort: The Jackson Heart Study.

TitleAtrial fibrillation in an African-American cohort: The Jackson Heart Study.
Publication TypeJournal Article
Year of Publication2018
AuthorsAustin, TR, Wiggins, KL, Blackshear, C, Yang, Y, Benjamin, EJ, Curtis, LH, Sotoodehnia, N, Correa, A, Heckbert, SR
JournalClin Cardiol
Date Published2018 Jul 02
ISSN1932-8737
Abstract<p><b>BACKGROUND: </b>Atrial fibrillation (AF) is an important public health problem across race/ethnic groups. Data from US cohort studies initiated in the 1980s suggest a higher prevalence of AF risk factors among African-Americans (AAs) than whites, but lower AF incidence. The Jackson Heart Study (JHS) is a community-based study of 5306 AAs recruited starting in 2000.</p><p><b>HYPOTHESIS: </b>Demographic, anthropometric, cardiovascular, and/or electrocardiographic factors are associated with AF incidence in JHS.</p><p><b>METHODS: </b>Using baseline participant characteristics and incident AF identified through hospital surveillance, study electrocardiogram, and Medicare claims, we estimated age- and sex-specific AF incidence rates, compared them with rates in AA participants in the Multi-Ethnic Study of Atherosclerosis (MESA) and Cardiovascular Health Study (CHS), and examined associations of cardiovascular risk factors with AF.</p><p><b>RESULTS: </b>A total of 66 participants had prevalent AF at baseline. Over an average follow-up of 8.5 years, 242 cases of incident AF were identified. Age- and sex-specific AF incidence rates in JHS were similar to those among AAs in MESA and appeared slightly lower than those among AAs in CHS. In an age- and sex-adjusted model, associations with incident AF were observed for modifiable risk factors: high body weight (HR = 1.23 per 15 kg, 95%CI 1.13-1.35), systolic blood pressure (HR = 1.29 per 20 mmHg, 95%CI 1.13-1.47), and current smoking (HR = 1.80, 95%CI 1.27-2.55). Risk estimates associated with these risk factors were only slightly attenuated after multivariable adjustments.</p><p><b>CONCLUSIONS: </b>These findings underscore the potential additional benefits of interventions for weight management, control of hypertension, and smoking cessation for the prevention of AF among AAs.</p>
DOI10.1002/clc.23020
Alternate JournalClin Cardiol
PubMed ID29968356
Grant ListN01 HC095166 / HC / WHI NIH HHS / United States
U01 HL080295 / HL / NHLBI NIH HHS / United States
UL1 TR001079 / TR / NCATS NIH HHS / United States
N01 HC085082 / HC / WHI NIH HHS / United States
N01 HC095165 / HC / WHI NIH HHS / United States
N01 HC085079 / HC / WHI NIH HHS / United States
R21 HL121348 / HL / NHLBI NIH HHS / United States
UL1 TR000040 / TR / NCATS NIH HHS / United States
R01 AG023629 / AG / NIA NIH HHS / United States
R01 HL127659 / HL / NHLBI NIH HHS / United States
N01 HC095159 / HC / WHI NIH HHS / United States
ePub date: 
18/07