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Atrial fibrillation in an African-American cohort: The Jackson Heart Study.
Tuesday,2018-09-18 16:26 America/Los_Angeles — ecterry
| Title | Atrial fibrillation in an African-American cohort: The Jackson Heart Study. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Austin, TR, Wiggins, KL, Blackshear, C, Yang, Y, Benjamin, EJ, Curtis, LH, Sotoodehnia, N, Correa, A, Heckbert, SR |
| Journal | Clin Cardiol |
| Date Published | 2018 Jul 02 |
| ISSN | 1932-8737 |
| Abstract | <p><b>BACKGROUND: </b>Atrial fibrillation (AF) is an important public health problem across race/ethnic groups. Data from US cohort studies initiated in the 1980s suggest a higher prevalence of AF risk factors among African-Americans (AAs) than whites, but lower AF incidence. The Jackson Heart Study (JHS) is a community-based study of 5306 AAs recruited starting in 2000.</p><p><b>HYPOTHESIS: </b>Demographic, anthropometric, cardiovascular, and/or electrocardiographic factors are associated with AF incidence in JHS.</p><p><b>METHODS: </b>Using baseline participant characteristics and incident AF identified through hospital surveillance, study electrocardiogram, and Medicare claims, we estimated age- and sex-specific AF incidence rates, compared them with rates in AA participants in the Multi-Ethnic Study of Atherosclerosis (MESA) and Cardiovascular Health Study (CHS), and examined associations of cardiovascular risk factors with AF.</p><p><b>RESULTS: </b>A total of 66 participants had prevalent AF at baseline. Over an average follow-up of 8.5 years, 242 cases of incident AF were identified. Age- and sex-specific AF incidence rates in JHS were similar to those among AAs in MESA and appeared slightly lower than those among AAs in CHS. In an age- and sex-adjusted model, associations with incident AF were observed for modifiable risk factors: high body weight (HR = 1.23 per 15 kg, 95%CI 1.13-1.35), systolic blood pressure (HR = 1.29 per 20 mmHg, 95%CI 1.13-1.47), and current smoking (HR = 1.80, 95%CI 1.27-2.55). Risk estimates associated with these risk factors were only slightly attenuated after multivariable adjustments.</p><p><b>CONCLUSIONS: </b>These findings underscore the potential additional benefits of interventions for weight management, control of hypertension, and smoking cessation for the prevention of AF among AAs.</p> |
| DOI | 10.1002/clc.23020 |
| Alternate Journal | Clin Cardiol |
| PubMed ID | 29968356 |
| Grant List | N01 HC095166 / HC / WHI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States UL1 TR001079 / TR / NCATS NIH HHS / United States N01 HC085082 / HC / WHI NIH HHS / United States N01 HC095165 / HC / WHI NIH HHS / United States N01 HC085079 / HC / WHI NIH HHS / United States R21 HL121348 / HL / NHLBI NIH HHS / United States UL1 TR000040 / TR / NCATS NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States R01 HL127659 / HL / NHLBI NIH HHS / United States N01 HC095159 / HC / WHI NIH HHS / United States |
ePub date:
18/07