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Meta-analysis of exome array data identifies six novel genetic loci for lung function.
Wednesday,2018-09-19 10:29 America/Los_Angeles — ecterry
| Title | Meta-analysis of exome array data identifies six novel genetic loci for lung function. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Jackson, VE, Latourelle, JC, Wain, LV, Smith, AV, Grove, ML, Bartz, TM, Obeidat, M'en, Province, MA, Gao, W, Qaiser, B, Porteous, DJ, Cassano, PA, Ahluwalia, TS, Grarup, N, Li, J, Altmaier, E, Marten, J, Harris, SE, Manichaikul, A, Pottinger, TD, Li-Gao, R, Lind-Thomsen, A, Mahajan, A, Lahousse, L, Imboden, M, Teumer, A, Prins, B, Lyytikäinen, L-P, Eiriksdottir, G, Franceschini, N, Sitlani, CM, Brody, JA, Bossé, Y, Timens, W, Kraja, A, Loukola, A, Tang, W, Liu, Y, Bork-Jensen, J, Justesen, JM, Linneberg, A, Lange, LA, Rawal, R, Karrasch, S, Huffman, JE, Smith, BH, Davies, G, Burkart, KM, Mychaleckyj, JC, Bonten, TN, Enroth, S, Lind, L, Brusselle, GG, Kumar, A, Stubbe, B, Kähönen, M, Wyss, AB, Psaty, BM, Heckbert, SR, Hao, K, Rantanen, T, Kritchevsky, SB, Lohman, K, Skaaby, T, Pisinger, C, Hansen, T, Schulz, H, Polasek, O, Campbell, A, Starr, JM, Rich, SS, Mook-Kanamori, DO, Johansson, A, Ingelsson, E, Uitterlinden, AG, Weiss, S, Raitakari, OT, Gudnason, V, North, KE, Gharib, SA, Sin, DD, Taylor, KD, O'Connor, GT, Kaprio, J, Harris, TB, Pederson, O, Vestergaard, H, Wilson, JG, Strauch, K, Hayward, C, Kerr, S, Deary, IJ, R Barr, G, de Mutsert, R, Gyllensten, U, Morris, AP, Ikram, AM, Probst-Hensch, N, Gläser, S, Zeggini, E, Lehtimäki, T, Strachan, DP, Dupuis, J, Morrison, AC, Hall, IP, Tobin, MD, London, SJ |
| Corporate/Institutional Authors | Understanding Society Scientific Group |
| Journal | Wellcome Open Res |
| Volume | 3 |
| Pagination | 4 |
| Date Published | 2018 |
| ISSN | 2398-502X |
| Abstract | <p> Over 90 regions of the genome have been associated with lung function to date, many of which have also been implicated in chronic obstructive pulmonary disease. We carried out meta-analyses of exome array data and three lung function measures: forced expiratory volume in one second (FEV ), forced vital capacity (FVC) and the ratio of FEV to FVC (FEV /FVC). These analyses by the SpiroMeta and CHARGE consortia included 60,749 individuals of European ancestry from 23 studies, and 7,721 individuals of African Ancestry from 5 studies in the discovery stage, with follow-up in up to 111,556 independent individuals. We identified significant (P<2·8x10 ) associations with six SNPs: a nonsynonymous variant in , which is predicted to be damaging, three intronic SNPs ( and ) and two intergenic SNPs near to and Expression quantitative trait loci analyses found evidence for regulation of gene expression at three signals and implicated several genes, including and . Further interrogation of these loci could provide greater understanding of the determinants of lung function and pulmonary disease.</p> |
| DOI | 10.12688/wellcomeopenres.12583.3 |
| Alternate Journal | Wellcome Open Res |
| PubMed ID | 30175238 |
| PubMed Central ID | PMC6081985 |
ePub date:
18/01