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Impact of lung-function measures on cardiovascular disease events in older adults with metabolic syndrome and diabetes.
Wednesday,2018-09-19 10:33 America/Los_Angeles — ecterry
| Title | Impact of lung-function measures on cardiovascular disease events in older adults with metabolic syndrome and diabetes. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Lee, HMu, Zhao, Y, Liu, MA, Yanez, D, Carnethon, M, R Barr, G, Wong, ND |
| Journal | Clin Cardiol |
| Volume | 41 |
| Issue | 7 |
| Pagination | 959-965 |
| Date Published | 2018 Jul |
| ISSN | 1932-8737 |
| Abstract | <p><b>BACKGROUND: </b>Individuals with metabolic syndrome (MetS) and diabetes (DM) are more likely to have decreased lung function and are at greater risk of cardiovascular disease (CVD).</p><p><b>HYPOTHESIS: </b>Lung-function measures can predict CVD events in older persons with MetS, DM, and neither condition.</p><p><b>METHODS: </b>We followed 4114 participants age ≥ 65 years with and without MetS or DM in the Cardiovascular Health Study. Cox regression examined the association of forced vital capacity (FVC) and 1-second forced expiratory volume (FEV ; percent of predicted values) with incident coronary heart disease and CVD events over 12.9 years.</p><p><b>RESULTS: </b>DM was present in 537 (13.1%) and MetS in 1277 (31.0%) participants. Comparing fourth vs first quartiles for FVC, risk of CVD events was 16% (HR: 0.84, 95% CI: 0.59-1.18), 23% (HR: 0.77, 95% CI: 0.60-0.99), and 30% (HR: 0.70, 95% CI: 0.58-0.84) lower in DM, MetS, and neither disease groups, respectively. For FEV , CVD risk was lower by 2% (HR: 0.98, 95% CI: 0.70-1.37), 26% (HR: 0.74, 95% CI: 0.59-0.93), and 31% (HR: 0.69, 95% CI: 0.57-0.82) in DM. Findings were strongest for predicting congestive heart failure (CHF) in all disease groups. C-statistics increased significantly with addition of FEV or FVC over risk factors for CVD and CHF among those with neither MetS nor DM.</p><p><b>CONCLUSIONS: </b>FEV and FVC are inversely related to CVD in older adults with and without MetS, but not DM (except for CHF); however, their value in incremental risk prediction beyond standard risk factors is limited mainly to metabolically healthier persons.</p> |
| DOI | 10.1002/clc.22985 |
| Alternate Journal | Clin Cardiol |
| PubMed ID | 29797803 |
ePub date:
18/05