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A large-scale exome array analysis of venous thromboembolism.
Monday,2019-03-11 13:58 America/Los_Angeles — ecterry
| Title | A large-scale exome array analysis of venous thromboembolism. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Lindström, S, Brody, JA, Turman, C, Germain, M, Bartz, TM, Smith, EN, Chen, M-H, Puurunen, M, Chasman, D, Hassler, J, Pankratz, N, Basu, S, Guan, W, Gyorgy, B, Ibrahim, M, Empana, J-P, Olaso, R, Jackson, R, Braekkan, SK, McKnight, B, Deleuze, J-F, O'Donnell, CJ, Jouven, X, Frazer, KA, Psaty, BM, Wiggins, KL, Taylor, K, Reiner, AP, Heckbert, SR, Kooperberg, C, Ridker, P, Hansen, J-B, Tang, W, Johnson, AD, Morange, P-E, Trégouët, DA, Kraft, P, Smith, NL, Kabrhel, C |
| Corporate/Institutional Authors | INVENT Consortium |
| Journal | Genet Epidemiol |
| Date Published | 2019 Jan 19 |
| ISSN | 1098-2272 |
| Abstract | <p>Although recent Genome-Wide Association Studies have identified novel associations for common variants, there has been no comprehensive exome-wide search for low-frequency variants that affect the risk of venous thromboembolism (VTE). We conducted a meta-analysis of 11 studies comprising 8,332 cases and 16,087 controls of European ancestry and 382 cases and 1,476 controls of African American ancestry genotyped with the Illumina HumanExome BeadChip. We used the seqMeta package in R to conduct single variant and gene-based rare variant tests. In the single variant analysis, we limited our analysis to the 64,794 variants with at least 40 minor alleles across studies (minor allele frequency [MAF] ~0.08%). We confirmed associations with previously identified VTE loci, including ABO, F5, F11, and FGA. After adjusting for multiple testing, we observed no novel significant findings in single variant or gene-based analysis. Given our sample size, we had greater than 80% power to detect minimum odds ratios greater than 1.5 and 1.8 for a single variant with MAF of 0.01 and 0.005, respectively. Larger studies and sequence data may be needed to identify novel low-frequency and rare variants associated with VTE risk.</p> |
| DOI | 10.1002/gepi.22187 |
| Alternate Journal | Genet. Epidemiol. |
| PubMed ID | 30659681 |
| Grant List | HL053375 / / National Heart, Lung, and Blood Institute / HHSN268201800001C / / National Heart, Lung, and Blood Institute / R01HL087652 / / National Heart, Lung, and Blood Institute / HHSN268201200036C / / National Heart, Lung, and Blood Institute / HL043201 / / National Heart, Lung, and Blood Institute / HL099355 / / National Heart, Lung, and Blood Institute / R01CA67262 / / National Heart, Lung, and Blood Institute / P01CA87969 / / National Cancer Institute / N01HC85083 / / National Heart, Lung, and Blood Institute / HL085251 / / National Heart, Lung, and Blood Institute / HHSN268201600001C / / National Heart, Lung, and Blood Institute / DK063491 / / National Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center / HHSN268201700001I / / National Heart, Lung, and Blood Institute / HL68639 / / National Heart, Lung, and Blood Institute / R01HL103612 / / National Heart, Lung, and Blood Institute / R01HL130114 / / National Heart, Lung, and Blood Institute / R01HL068986 / / National Heart, Lung, and Blood Institute / UL1TR000124 / / National Center for Advancing Translational Sciences / N01HC85080 / / National Heart, Lung, and Blood Institute / HL060739 / / National Heart, Lung, and Blood Institute / HHSN268201700003I / / National Heart, Lung, and Blood Institute / ANR-10-IAHU / / ICAN Institute for Cardiometabolism and Nutrition / N01HC85086 / / National Heart, Lung, and Blood Institute / HHSN268201600003C / / National Heart, Lung, and Blood Institute / HL043851 / / National Heart, Lung, and Blood Institute / N01-HC-25195 / / National Heart, Lung, and Blood Institute / R01HL105756 / / National Heart, Lung, and Blood Institute / R01CA50385 / / National Heart, Lung, and Blood Institute / R01CA49449 / / National Cancer Institute / ANR-10-LABX-0013 / / GENMED Laboratory of Excellence on Medical Genomics / HL095080 / / National Heart, Lung, and Blood Institute / HL040628 / / National Heart, Lung, and Blood Institute / UM1CA182913 / / National Cancer Institute / R01HL034594 / / National Heart, Lung, and Blood Institute / P01CA055075 / / National Heart, Lung, and Blood Institute / U01HL080295 / / National Heart, Lung, and Blood Institute / HL073410 / / National Heart, Lung, and Blood Institute / 5RC2HL102419 / / NIH American Recovery and Reinvestment Act / R01HL120393 / / National Heart, Lung, and Blood Institute / CA047988 / / National Cancer Institute / HHSN268201700005I / / National Heart, Lung, and Blood Institute / N01HC85079 / / National Heart, Lung, and Blood Institute / N01HC85081 / / National Heart, Lung, and Blood Institute / N01HC55222 / / National Heart, Lung, and Blood Institute / HHSN268200800007C / / National Heart, Lung, and Blood Institute / R01HL35464 / / National Heart, Lung, and Blood Institute / HL74745 / / National Heart, Lung, and Blood Institute / HL080467 / / National Heart, Lung, and Blood Institute / N01HC85082 / / National Heart, Lung, and Blood Institute / R01HL116854 / / National Heart, Lung, and Blood Institute / HL068986 / / National Heart, Lung, and Blood Institute / R01AG023629 / / US Department of Health and Human Services, National Institutes of Health, National Institute of Aging / HHSN268201600004C / / National Heart, Lung, and Blood Institute / HHSN268201700002I / / National Heart, Lung, and Blood Institute / R01HL59367 / / National Heart, Lung, and Blood Institute / HHSN268201600002C / / National Heart, Lung, and Blood Institute / HHSN268201600018C / / National Heart, Lung, and Blood Institute / R01HL088521 / / National Heart, Lung, and Blood Institute / |
ePub date:
19/01