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Harmonization of Respiratory Data From 9 US Population-Based Cohorts: The NHLBI Pooled Cohorts Study.
Wednesday,2019-05-22 16:31 America/Los_Angeles — ecterry
| Title | Harmonization of Respiratory Data From 9 US Population-Based Cohorts: The NHLBI Pooled Cohorts Study. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Oelsner, EC, Balte, PP, Cassano, PA, Couper, D, Enright, PL, Folsom, AR, Hankinson, J, Jacobs, DR, Kalhan, R, Kaplan, R, Kronmal, R, Lange, L, Loehr, LR, London, SJ, Acien, ANavas, Newman, AB, O'Connor, GT, Schwartz, JE, Smith, LJ, Yeh, F, Zhang, Y, Moran, AE, Mwasongwe, S, White, WB, Yende, S, R Barr, G |
| Journal | Am J Epidemiol |
| Volume | 187 |
| Issue | 11 |
| Pagination | 2265-2278 |
| Date Published | 2018 Nov 01 |
| ISSN | 1476-6256 |
| Abstract | <p>Chronic lower respiratory diseases (CLRDs) are the fourth leading cause of death in the United States. To support investigations into CLRD risk determinants and new approaches to primary prevention, we aimed to harmonize and pool respiratory data from US general population-based cohorts. Data were obtained from prospective cohorts that performed prebronchodilator spirometry and were harmonized following 2005 ATS/ERS standards. In cohorts conducting follow-up for noncardiovascular events, CLRD events were defined as hospitalizations/deaths adjudicated as CLRD-related or assigned relevant administrative codes. Coding and variable names were applied uniformly. The pooled sample included 65,251 adults in 9 cohorts followed-up for CLRD-related mortality over 653,380 person-years during 1983-2016. Average baseline age was 52 years; 56% were female; 49% were never-smokers; and racial/ethnic composition was 44% white, 22% black, 28% Hispanic/Latino, and 5% American Indian. Over 96% had complete data on smoking, clinical CLRD diagnoses, and dyspnea. After excluding invalid spirometry examinations (13%), there were 105,696 valid examinations (median, 2 per participant). Of 29,351 participants followed for CLRD hospitalizations, median follow-up was 14 years; only 5% were lost to follow-up at 10 years. The NHLBI Pooled Cohorts Study provides a harmonization standard applied to a large, US population-based sample that may be used to advance epidemiologic research on CLRD.</p> |
| DOI | 10.1093/aje/kwy139 |
| Alternate Journal | Am. J. Epidemiol. |
| PubMed ID | 29982273 |
| PubMed Central ID | PMC6211239 |
| Grant List | HHSN268201300026C / HL / NHLBI NIH HHS / United States U01 HL041642 / HL / NHLBI NIH HHS / United States N01HC95160 / HL / NHLBI NIH HHS / United States U01 HL041654 / HL / NHLBI NIH HHS / United States N01HC95163 / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States HHSN268201500001C / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States N01HC95169 / HL / NHLBI NIH HHS / United States R01 HL077612 / HL / NHLBI NIH HHS / United States N01HC65236 / HL / NHLBI NIH HHS / United States HHSN268201300048C / HL / NHLBI NIH HHS / United States N01HC65235 / HL / NHLBI NIH HHS / United States RC1 HL100543 / HL / NHLBI NIH HHS / United States N01HC95164 / HL / NHLBI NIH HHS / United States HHSN268201300025C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States U01 HL041652 / HL / NHLBI NIH HHS / United States N01HC95162 / HL / NHLBI NIH HHS / United States R01 NR012459 / NR / NINR NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01HC65234 / HL / NHLBI NIH HHS / United States R01 HL093081 / HL / NHLBI NIH HHS / United States N01HC95168 / HL / NHLBI NIH HHS / United States R21 HL121457 / HL / NHLBI NIH HHS / United States HHSN268201300027C / HL / NHLBI NIH HHS / United States N01HC65233 / HL / NHLBI NIH HHS / United States HHSN268201300049C / HL / NHLBI NIH HHS / United States R01 HL109315 / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States HHSN268201700001I / HL / NHLBI NIH HHS / United States HHSN268200900041C / HL / NHLBI NIH HHS / United States HHSN268201300028C / HL / NHLBI NIH HHS / United States N01HC65237 / HL / NHLBI NIH HHS / United States HHSN268201700004I / HL / NHLBI NIH HHS / United States N01HC95165 / HL / NHLBI NIH HHS / United States N01HC95159 / HL / NHLBI NIH HHS / United States HHSN268201500001I / HL / NHLBI NIH HHS / United States R21 HL129924 / HL / NHLBI NIH HHS / United States N01HC95161 / HL / NHLBI NIH HHS / United States HHSN268201300047C / HL / NHLBI NIH HHS / United States HHSN268201300050C / HL / NHLBI NIH HHS / United States R01 HL109319 / HL / NHLBI NIH HHS / United States R01 AG028050 / AG / NIA NIH HHS / United States HHSN268201300003C / HG / NHGRI NIH HHS / United States HHSN268201000021C / HL / NHLBI NIH HHS / United States R01 HL109284 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC95167 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC25195 / HL / NHLBI NIH HHS / United States U01 HL065521 / HL / NHLBI NIH HHS / United States HHSN268201300046C / HL / NHLBI NIH HHS / United States HHSN268201700002I / HL / NHLBI NIH HHS / United States HHSN268201700005I / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01HC95166 / HL / NHLBI NIH HHS / United States HHSN268201300029C / HL / NHLBI NIH HHS / United States K23 HL130627 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States R01 HL109301 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States R01 HL122477 / HL / NHLBI NIH HHS / United States HHSN268201700003I / HL / NHLBI NIH HHS / United States R01 HL109282 / HL / NHLBI NIH HHS / United States U01 HL065520 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States P30 ES009089 / ES / NIEHS NIH HHS / United States |
ePub date:
18/11