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Biochemical markers of bone turnover and risk of incident hip fracture in older women: the Cardiovascular Health Study.
Monday,2019-07-29 14:03 America/Los_Angeles — ecterry
| Title | Biochemical markers of bone turnover and risk of incident hip fracture in older women: the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Massera, D, Xu, S, Walker, MD, Valderrábano, RJ, Mukamal, KJ, Ix, JH, Siscovick, DS, Tracy, RP, Robbins, JA, Biggs, ML, Xue, X, Kizer, JR |
| Journal | Osteoporos Int |
| Date Published | 2019 Jun 21 |
| ISSN | 1433-2965 |
| Abstract | <p>The relationships of osteocalcin (OC) and C-telopeptide of type I collagen (CTX) with long-term incidence of hip fracture were examined in 1680 post-menopausal women from a population-based study. CTX, but not OC, levels were associated with incident hip fracture in these participants, a relationship characterized by an inverted U-shape.</p><p><b>INTRODUCTION: </b>We sought to investigate the relationships of OC, a marker of bone formation, and CTX, a marker of bone resorption, with long-term incidence of hip fracture in older women.</p><p><b>METHODS: </b>We included 1680 women from the population-based Cardiovascular Health Study (mean [SD] age 74.5 [5.0] years). The longitudinal association of both markers with incidence of hip fracture was examined using multivariable Cox models.</p><p><b>RESULTS: </b>During a median follow-up of 12.3 years, 288 incident hip fractures occurred. Linear spline analysis did not demonstrate an association between OC levels and incident hip fracture. By contrast, increasing levels of CTX up to the middle-upper range were associated with a significantly greater risk of hip fracture (HR = 1.52 per SD increment, 95% CI = 1.10-2.09), while further increases were associated with a marginally non-significant lower risk (HR = 0.80 per SD increment, 95% CI = 0.63-1.01), after full adjustment for potential confounders. In analyses of quartiles, CTX exhibited a similar inverted U-shaped relationship with incident fracture after adjustment, with a significant association observed only for the comparison of quartile 3 to quartile 1 (HR = 1.63, 95% CI = 1.10-2.43). In a subset with available measures, both OC and CTX were inversely associated with bone mineral density of the hip.</p><p><b>CONCLUSION: </b>CTX, but not OC, levels were associated with incident hip fracture in post-menopausal women, a relationship characterized by an inverted U-shape. These findings highlight the complex relationship of bone turnover markers with hip fracture risk.</p> |
| DOI | 10.1007/s00198-019-05043-1 |
| Alternate Journal | Osteoporos Int |
| PubMed ID | 31227885 |
| Grant List | HHSN268201200036C / / National Heart, Lung, and Blood Institute / HHSN268200800007C / / National Heart, Lung, and Blood Institute / HHSN268201800001C / / National Heart, Lung, and Blood Institute / N01HC55222 / / National Heart, Lung, and Blood Institute / N01HC85079 / / National Heart, Lung, and Blood Institute / N01HC85080 / / National Heart, Lung, and Blood Institute / N01HC85081 / / National Heart, Lung, and Blood Institute / N01HC85082 / / National Heart, Lung, and Blood Institute / N01HC85083 / / National Heart, Lung, and Blood Institute / N01HC85086 / / National Heart, Lung, and Blood Institute / U01HL080295 / / National Heart, Lung, and Blood Institute / U01HL130114 / / National Heart, Lung, and Blood Institute / K24HL135413 / / National Heart, Lung, and Blood Institute / N/A / / National Institute of Neurological Disorders and Stroke / R01AG023629 / / National Institute on Aging / The Glorney-Raisbeck Fellowship Program / / Corlette Glorney Foundation and The New York Academy of Medicine / |
ePub date:
19/06